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Displaying Results 101 - 125 of 139 on page 5 of 6

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Recent Advances in the Application of Metabolomics for Nutrition and Health (2020)

González-Peña, Diana; Brennan, Lorraine

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Parenting support and parental participation work package final report: Tusla's programme for prevention, partnership and family support (2018)

Crosse, Rosemary; Devaney, Carmel

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Parenting support: Policy and practice in the Irish context (2018)

Connolly, Nuala; Devaney, Carmel

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Patients and health professionals' perspectives on the sociocultural influences on secondary cardiac behaviour: a qualitative study of the implications in policy and practice (2018)

Ononeze, V.

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Perceived risk of death in older primary care patients (2016)

Teixeira, Laetitia; Azevedo, Maria João; Alves, Sara; Duarte, Mafalda; O'Caoimh, R...

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Perceived risk of death in older primary care patients (2018)

Teixeira, Laetitia; Azevedo, Maria João; Alves, Sara; Duarte, Mafalda; O’Caoimh, Rónán;...

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Perceptions of animal physiotherapy amongst Irish veterinary surgeons. (2006)

Doyle, Aoife; Horgan, Frances

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Perceptions Regarding Male Suicide and Preventative Services in Co. Kilkenny (2005)

Butler, Louise; Phelan, Jim

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Pravastatin reduces marfan aortic dilation (2018)

McLoughlin, D.; McGuinness, J.; Byrne, J.; Terzo, E.; Huuskonen, V.; McAllister, H.; Bl...

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Prediction of breast cancer risk based on profiling with common genetic variants (2018)

Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mar...

Prediction of breast cancer risk based on profiling with common genetic variants (2018)

Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mark N.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Brown, Judith; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Peto, Julian

Abstract:

Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates. Results: There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing brea...

http://hdl.handle.net/10379/12688

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Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients (2018)

Maharaj, C H.; Kallam, S R.; Malik, A; Hassett, P; Grady, D; Laffey, J G.

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Prevention of striae gravidarum (2020)

Brennan, Miriam

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Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries (2019)

Hegerl, Ulrich; Maxwell, Margaret; Harris, Fiona; Koburger, Nicole; Mergl, Roland; Szék...

Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries (2019)

Hegerl, Ulrich; Maxwell, Margaret; Harris, Fiona; Koburger, Nicole; Mergl, Roland; Székely, András; Arensman, Ella; Van Audenhove, Chantal; Larkin, Celine; Toth, Mónika Ditta; Quintão, Sónia; Värnik, Airi; Genz, Axel; Sarchiapone, Marco; McDaid, David; Schmidtke, Armin; Purebl, György; Coyne, James C.; Gusmão, Ricardo

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The ‘European Alliance Against Depression’ community-based intervention approach simultaneously targets depression and suicidal behaviour by a multifaceted community based intervention and has been implemented in more than 115 regions worldwide. The two main aims of the European Union funded project “Optimizing Suicide Prevention Programmes and Their Implementation in Europe” were to optimise this approach and to evaluate its implementation and impact. This paper reports on the primary outcome of the intervention (the number of completed and attempted suicides combined as ‘suicidal acts’) and on results concerning process evaluation analysis. Interventions were implemented in four European cities in Germany, Hungary, Portugal and Ireland, with matched control sites. The intervention comprised activities with predefined minimal intensity at four levels: training of primary care providers, a public awareness campaign, training of community facilitators, support for patients and their ...

http://hdl.handle.net/10468/9353

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Public awareness work package final report: Tusla's programme for prevention, partnership and family support (2019)

McGregor, Caroline; Canavan, John; O'Connor, Patricia

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Results from a european multicenter randomized trial of physical activity and/or healthy eating to reduce the risk of gestational diabetes mellitus: the dali lifestyle pilot (2018)

Simmons, David; Jelsma, Judith G.M.; Galjaard, Sander; Devlieger, Roland; van Assche, A...

Results from a european multicenter randomized trial of physical activity and/or healthy eating to reduce the risk of gestational diabetes mellitus: the dali lifestyle pilot (2018)

Simmons, David; Jelsma, Judith G.M.; Galjaard, Sander; Devlieger, Roland; van Assche, Andre; Jans, Goele; Corcoy, Rosa; Adelantado, Juan M.; Dunne, Fidelma; Desoye, Gernot; Harreiter, Jürgen; Kautzky-Willer, Alexandra; Damm, Peter; Mathiesen, Elisabeth R.; Jensen, Dorte M.; Andersen, Lise Lotte; Lapolla, Annunziata; Dalfra, Maria; Bertolotto, Alessandra; Wender-Ozegowska, Ewa

Abstract:

OBJECTIVE Ways to prevent gestational diabetes mellitus (GDM) remain unproven. We compared the impact of three lifestyle interventions (healthy eating [HE], physical activity [PA], and both HE and PA [HE+PA]) on GDM risk in a pilot multicenter randomized trial. RESEARCH DESIGN AND METHODS Pregnant women at risk for GDM (BMI &gt;= 29 kg/m(2)) from nine European countries were invited to undertake a 75-g oral glucose tolerance test before 20 weeks' gestation. Those without GDM were randomized to HE, PA, or HE+PA. Women received five face-to-face and four optional telephone coaching sessions, based on the principles of motivational interviewing. A gestational weight gain (GWG) &lt;5 kg was targeted. Coaches received standardized training and an intervention toolkit. Primary outcome measures were GWG, fasting glucose, and insulin sensitivity (HOMA) at 35-37 weeks. RESULTS Among the 150 trial participants, 32% developed GDM by 35-37 weeks and 20% achieved GWG &am...

http://hdl.handle.net/10379/13919

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Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial (2018)

Anand, Sonia S; Bosch, Jackie; Eikelboom, John W; Connolly, Stuart J; Diaz, Rafael; Wid...

Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial (2018)

Anand, Sonia S; Bosch, Jackie; Eikelboom, John W; Connolly, Stuart J; Diaz, Rafael; Widimsky, Peter; Aboyans, Victor; Alings, Marco; Kakkar, Ajay K; Keltai, Katalin; Maggioni, Aldo P; Lewis, Basil S; Störk, Stefan; Zhu, Jun; Lopez-Jaramillo, Patricio; O'Donnell, Martin; Commerford, Patrick J; Vinereanu, Dragos; Pogosova, Nana; Ryden, Lars

Abstract:

Background Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. Methods This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0.90. After a 30-day run-in period, patients were randomly assigned (1:1:1) to receive oral rivaroxaban (2.5 mg twice a day) plus aspirin (100 mg once a day), rivaroxab...

http://hdl.handle.net/10379/10246