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Displaying Results 51 - 75 of 208 on page 3 of 9
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Determinants of respirable crystalline silica exposure among stoneworkers involved in stone restoration work
(2018)
Determinants of respirable crystalline silica exposure among stoneworkers involved in stone restoration work
(2018)
Abstract:
Objectives: Crystalline silica occurs as a significant component of many traditional materials used in restoration stonework, and stoneworkers who work with these materials are potentially exposed to stone dust containing respirable crystalline silica (RCS). Exposure to RCS can result in the development of a range of adverse health effects, including silicosis and lung cancer. An understanding of the determinants of RCS exposure is important for selecting appropriate exposure controls and in preventing occupational diseases. The objectives of this study were to quantify the RCS exposure of stoneworkers involved in the restoration and maintenance of heritage properties and to identify the main determinants of RCS exposure among this occupational group. Methods: An exposure assessment was carried out over a 3-year period amongst a group of stonemasons and stone cutters involved in the restoration and maintenance of heritage buildings in Ireland. Personal air samples (n 103) with corre...
http://hdl.handle.net/10379/11864
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Dietary adequacy of vitamin D and calcium among Inuit and Inuvialuit women of child-bearing age in Arctic Canada: a growing concern
(2013)
Kolahdooz, Fariba; Barr, Alison; Roache, Cindy; Sheehy, Tony; Corriveau, Andre; Sharma,...
Dietary adequacy of vitamin D and calcium among Inuit and Inuvialuit women of child-bearing age in Arctic Canada: a growing concern
(2013)
Kolahdooz, Fariba; Barr, Alison; Roache, Cindy; Sheehy, Tony; Corriveau, Andre; Sharma, Sangita
Abstract:
Background: Arctic populations are at an increased risk of vitamin D inadequacy due to geographic latitude and a nutrition transition. This study aimed to assess the adequacy of dietary vitamin D and calcium among women of child-bearing age in Arctic Canada. Methods: This study collected data from 203 randomly selected women of child-bearing age (19-44 years) in Nunavut and the Northwest Territories of Arctic Canada. Cross-sectional surveys using a validated quantitative food frequency questionnaire were analysed to determine the dietary adequacy of vitamin D and calcium and summarize the top foods contributing to vitamin D and calcium intake among traditional food eaters (TFE) and non-traditional food eaters (NTFE). Results: The response rate was between 69-93% depending on the community sampled. Mean BMIs for both TFE and NTFE were above the normal range. Traditional food eaters had a significantly higher median vitamin D intake compared with non-traditional eaters (TFE = 5.13±5.3...
http://hdl.handle.net/10468/2360
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Different effectiveness of helicobacter pylori lipopolysaccharides with or without lewisxy determinants in stimulating the secretion of proinflammatory cytokines il-8 and tnf-α by peripheral blood mononuclear leukocytes
(2018)
Rudnicka, Karolina; Grębowska, Aneta; Moran, Anthony P.; Matusiak, Agnieszka; Walencka,...
Different effectiveness of helicobacter pylori lipopolysaccharides with or without lewisxy determinants in stimulating the secretion of proinflammatory cytokines il-8 and tnf-α by peripheral blood mononuclear leukocytes
(2018)
Rudnicka, Karolina; Grębowska, Aneta; Moran, Anthony P.; Matusiak, Agnieszka; Walencka, Maria; Miszczyk, Eliza; Bąk-Romaniszyn, Leokadia; Czkwianianc, Elżbieta; Płaneta-Małecka, Izabela; Rudnicka, Wiesława; Chmiela, Magdalena
Abstract:
Introduction: Helicobacter pylori is an aetiological agent of chronic gastritis, gastric and duodenal ulcers, and gastric cancers. It is suggested that H. pylori must have undergone evolutionary changes that enable the bacteria to overcome the host immune response. The molecular mimicry between Lewis (Le) determinants present in H. pylori lipopolysaccharide (LPS) and on the host cells may play a role in the outcome of H. pylori infections. Aim: In this study we investigated the production of inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 8 (IL-8), by human peripheral blood mononuclear leukocytes (PBML) from H. pylori infected (11) and uninfected (10) subjects (21 women, aged 25-50 years), in response to H. pylori-LPS with LeXY(+) or without LeXY(-) determinants. Material and methods: Peripheral blood was collected using the Vacutainer heparin system and constituted a source of total or monocyte and lymphocyte enriched PBML fractions. Tumour necrosis ...
http://hdl.handle.net/10379/13726
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Effects of standard coagulant agents on the dielectric properties of fresh human blood
(2018)
Salahuddin, Saqib; O'Halloran, Martin; Porter, Emily; Farrugia, Lourdes; Bonello, ...
Effects of standard coagulant agents on the dielectric properties of fresh human blood
(2018)
Salahuddin, Saqib; O'Halloran, Martin; Porter, Emily; Farrugia, Lourdes; Bonello, Julian; Sammut, Charles V.; Wismayer, P. Schembri
Abstract:
In this paper, the effects of coagulation and temperature on the dielectric properties of human blood are investigated over the frequency range of 400 MHz - 20 GHz using freshly extracted blood samples. The dielectric properties are measured using blood in four different sample collection tubes (bottles): one containing pure whole blood, two containing different anticoagulant agents, and one containing clot activator and serum separator. The collected data indicates that additive agents can have a significant impact on the measured dielectric properties of blood, both immediately after the sample is taken, and over longer time periods. This is an important finding as it suggests that measurements of blood properties conducted on sample repositories, or tissue banks, may not be representative of natural blood properties. Further, the results demonstrate that the dielectric properties of normal blood vary over time due to coagulation. Different clotting rates lead to dielectric proper...
http://hdl.handle.net/10379/13773
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Effects of znf804a on auditory p300 response in schizophrenia
(2018)
O'Donoghue, T; Morris, D W; Fahey, C; Da Costa, A; Moore, S; Cummings, E; Leicht, ...
Effects of znf804a on auditory p300 response in schizophrenia
(2018)
O'Donoghue, T; Morris, D W; Fahey, C; Da Costa, A; Moore, S; Cummings, E; Leicht, G; Karch, S; Hoerold, D; Tropea, D; Foxe, J J; Gill, M; Corvin, A; Donohoe, G
Abstract:
The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n = 97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF80...
http://hdl.handle.net/10379/13226
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Elevated herv-k mrna expression in pbmc is associated with a prostate cancer diagnosis particularly in older men and smokers
(2018)
Wallace, Tiffany A.; Downey, Ronan F.; Seufert, Caleb J.; Schetter, Aaron; Dorsey, Tiff...
Elevated herv-k mrna expression in pbmc is associated with a prostate cancer diagnosis particularly in older men and smokers
(2018)
Wallace, Tiffany A.; Downey, Ronan F.; Seufert, Caleb J.; Schetter, Aaron; Dorsey, Tiffany H.; Johnson, Carol A.; Goldman, Radoslav; Loffredo, Christopher A.; Yan, Peisha; Sullivan, Francis J.; Giles, Francis J.; Wang-Johanning, Feng; Ambs, Stefan; Glynn, Sharon A.
Abstract:
Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for near intact retroviruses. We hypothesized that HERV-K reactivation could serve as a non-invasive early disease detection marker for prostate cancer. We evaluated HERV-K gag messenger RNA (mRNA) expression in blood samples of African-American and European-American men using a case-control design via quantitative real-time PCR. Additionally, we examined HERV-K envelope protein expression in prostate tumors by immunohistochemistry. HERV-K envelope protein was commonly upregulated in prostate tumors, but more so in tumors of African-American than European-American patients (61% versus 40%, P < 0.01). Examining HERV-K gag expression in peripheral blood mononuclear cells (PBMC) from 294 cases and 135 healthy men, we found that the abundance of HERV-K gag message ...
http://hdl.handle.net/10379/14335
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End stage kidney disease from scleroderma in the united states, 1996 to 2012
(2018)
Sexton, Donal J.; Reule, Scott; Foley, Robert N.
End stage kidney disease from scleroderma in the united states, 1996 to 2012
(2018)
Sexton, Donal J.; Reule, Scott; Foley, Robert N.
Abstract:
Introduction: Although the management of scleroderma continues to evolve, it is unknown whether the burden of end-stage kidney disease (ESKD) treated with maintenance renal replacement therapy from SD has changed. Methods: We examined United States Renal Data System data (n = 1,677,303) for the years 1996 to 2012 to quantify the incidence and outcomes of ESKD from scleroderma treated with renal replacement therapy (n = 2398). Outcomes assessed through demography-matched scleroderma-positive/scleroderma-negative comparisons included recovery of kidney function, mortality, listing for transplant, renal transplantations, and graft failure. Results: Overall ESKD rates from scleroderma were 0.5 per million per year. Adjusted incidence ratios fell over time, to 0.42 in 2012 (vs. 1996, 95% confidence interval [CI] = 0.32-0.54, P < 0.001). Adjusted incidence ratios for ESKD from scleroderma fell over time in both sexes, all age, race, and ethnicity categories except age &...
http://hdl.handle.net/10379/13868
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Estimating biomass, fishing mortality, and "total allowable discards" for surveyed non-target fish
(2018)
Shephard, S.; Reid, D. G.; Gerritsen, H. D.; Farnsworth, K. D.
Estimating biomass, fishing mortality, and "total allowable discards" for surveyed non-target fish
(2018)
Shephard, S.; Reid, D. G.; Gerritsen, H. D.; Farnsworth, K. D.
Abstract:
Demersal fisheries targeting a few high-value species often catch and discard other "non-target" species. It is difficult to quantify the impact of this incidental mortality when population biomass of a non-target species is unknown. We calculate biomass for 14 demersal fish species in ICES Area VIIg (Celtic Sea) by applying species-and length-based catchability corrections to catch records from the Irish Groundfish Survey (IGFS). We then combine these biomass estimates with records of commercial discards (and landings for marketable non-target species) to calculate annual harvesting rates (HR) for each study species. Uncertainty is incorporated into estimates of both biomass andHR. Our survey-based HR estimates for cod and whiting compared well with HR-converted fishing mortality (F) estimates from analytical assessments for these two stocks. Of the non-target species tested, red gurnard (Chelidonichthys cuculus) recorded some annual HRs greater than those...
http://hdl.handle.net/10379/13894
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Estimating Risk of Failure of Engineering Structures using Predictive Likelihood
(2006)
Caprani, Colin C.; Bordallo-Ruiz, A.; O'Brien, E. J.
Estimating Risk of Failure of Engineering Structures using Predictive Likelihood
(2006)
Caprani, Colin C.; Bordallo-Ruiz, A.; O'Brien, E. J.
Abstract:
It has been common engineering practice to define characteristic values for loading and capacity of structures in order to assess the structural capacity of existing structures. This approach, yet practical and intuitive, lead to the comparison of deterministic values (characteristic values) that had to represent all the variability of the problem and is considered to be conservative, as usually loading is overestimated and capacity underestimated, yielding to calculations with high safety margins for the extreme events. Probabilistics methods have tried to overcom e this limitation by computing the overall probability of failure (Pf) for the lifetime of the structure, taking into account the real probabilistic distribution of both loading and resistance. In this paper, Predictive Likelihood (PL) is presented as a powerful method to determine the lifetime distribution for loading and resistance. From these lifetime distributions the probability of failure is computed. An example of ...
https://arrow.dit.ie/engschcivcon/25
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Evaluation of early metabolic and vascular risk in children of parents with early ischaemic heart disease
(2017)
Macken, Alan P
Evaluation of early metabolic and vascular risk in children of parents with early ischaemic heart disease
(2017)
Macken, Alan P
Abstract:
Atherosclerotic cardiovascular disease is the leading cause of death in Ireland and throughout the developed world. Where a parent has had an early cardiac event, their offspring are at risk of developing heart problems in the future. In this study, we assessed children aged between 8-14 years, whose fathers had premature cardiac (or heart) disease defined as early heart attacks, heart bypass surgery, or angioplasty and evaluated these children [subjects, n=38] for early evidence of atherosclerosis and metabolic abnormalities and compared them to children whose parents do not have known early heart disease [controls, n=25]. The following evaluations were performed: anthropometrics; medical history; family history; fasting lipids; oral glucose tolerance testing; glycosylated haemoglobin (HbA1c); fibrinogen; Carotid Intima Media Thickness measurement; assessment of endothelial function by peripheral applanation tonometry; 24-hour ambulatory blood pressure recordings; blood pressure in...
http://hdl.handle.net/10344/6083
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Evaluation of variants in the chek2, brip1 and palb2 genes in an irish breast cancer cohort
(2018)
McInerney, N. M.; Miller, N.; Rowan, A.; Colleran, G.; Barclay, E.; Curran, C.; Kerin, ...
Evaluation of variants in the chek2, brip1 and palb2 genes in an irish breast cancer cohort
(2018)
McInerney, N. M.; Miller, N.; Rowan, A.; Colleran, G.; Barclay, E.; Curran, C.; Kerin, M. J.; Tomlinson, I. P.; Sawyer, E.
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It has been proposed that rare variants within the double strand break repair genes CHEK2, BRIP1 and PALB2 predispose to breast cancer. The aim of this study was to evaluate the prevalence of these variants in an Irish breast cancer cohort and determine their contribution to the development of breast cancer in the west of Ireland. We evaluated the presence of CHEK2_1100delC variant in 903 breast cancer cases and 1,016 controls. Six previously described variants within BRIP1 and five within PALB2 were screened in 192 patients with early-onset or familial breast cancer. Where a variant was evident, it was then examined in the remainder of our 711 unselected breast cancer cases. CHEK2_1100delC was found in 5/903 (0.5%) breast cancer cases compared to 1/1016 (0.1%) controls. One mutation at BRIP1 (2392 C > T) was identified in the early-onset/familial cohort. Examination of this variant in the remainder of our cohort (711 cases) failed to identify any additional cases. None o...
http://hdl.handle.net/10379/12816
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Experience of miscarriage: an interpretative phenomenological analysis
(2017)
Meaney, Sarah; Corcoran, Paul; Spillane, Niamh; O'Donoghue, Keelin
Experience of miscarriage: an interpretative phenomenological analysis
(2017)
Meaney, Sarah; Corcoran, Paul; Spillane, Niamh; O'Donoghue, Keelin
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Objective: The objective of the study was to explore the experiences of those who have experienced miscarriage, focusing on men's and women's accounts of miscarriage. Design: This was a qualitative study using a phenomenological framework. Following in-depth semistructured interviews, analysis was undertaken in order to identify superordinate themes relating to their experience of miscarriage. Setting: A large tertiary-level maternity hospital in Ireland. Participants: A purposive sample of 16 participants, comprising 10 women and 6 men, was recruited. Results: 6 superordinate themes in relation to the participant's experience of miscarriage were identified: (1) acknowledgement of miscarriage as a valid loss; (2) misperceptions of miscarriage; (3) the hospital environment, management of miscarriage; (4) support and coping; (5) reproductive history; and (6) implications for future pregnancies. Conclusions: One of the key findings illustrates a need for increased aware...
http://hdl.handle.net/10468/3905
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Explanations for social inequalities in preterm delivery in the prospective lifeways cohort in the republic of ireland
(2018)
Niedhammer, I.; Murrin, C.; O'Mahony, D.; Daly, S.; Morrison, J. J.; Kelleher, C. ...
Explanations for social inequalities in preterm delivery in the prospective lifeways cohort in the republic of ireland
(2018)
Niedhammer, I.; Murrin, C.; O'Mahony, D.; Daly, S.; Morrison, J. J.; Kelleher, C. C.; ,
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Background: Social inequalities in pregnancy outcomes have been extensively described but studies that explain these inequalities comprehensively are lacking. This analysis evaluated the contribution of material, psychosocial, behavioural, nutritional and obstetrical factors in explaining social inequalities in preterm delivery. Methods: The data were based on a prospective cohort of 1109 Irish pregnant women. Preterm delivery was obtained from clinical hospital records. Socio-economic status was measured using educational level. The contribution of the above factors in explaining the association between educational level and preterm delivery was examined using Cox models. Results: Educational level was found to be a significant predictive factor of preterm delivery; women with low educational level were more likely to have a preterm delivery [hazard ratio (HR) = 2.14, 95% confidence interval (95% CI): 1.04-4.38)] after adjustment for age and parity. Rented and crowded home, smoking...
http://hdl.handle.net/10379/13129
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Exploring breast cancer and screening awareness among Irish women with intellectual disabilities
(2018)
Reidy, Mary; Denieffe, Suzanne; Foran, Sinéad
Exploring breast cancer and screening awareness among Irish women with intellectual disabilities
(2018)
Reidy, Mary; Denieffe, Suzanne; Foran, Sinéad
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Accessible Summary: We asked women with intellectual disabilities what they knew about breast cancer and screening programmes. We asked women what would put them off going to see a doctor whether they found something wrong with their breast. Most of those we asked knew that a lump was a warning sign for breast cancer. Most of those we asked did not know about the risk factors for breast cancer. Many women did not know much about the breast screening programme. Many women said they would be worried about what the doctor might find. Improving breast cancer and screening awareness is important for women with intellectual disabilities. Women with intellectual disabilities need to be taught more about breast cancer and screening. Abstract: Background: Internationally, it is known that there are gaps in cancer and screening awareness among women with intellectual disabilities. Little is known about this awareness among Irish women with intellectual disabilities. The aim of this study was ...
http://hdl.handle.net/10468/6175
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Extreme global equity market risk
(2012)
Cotter, John; Dowd, Kevin
Extreme global equity market risk
(2012)
Cotter, John; Dowd, Kevin
Abstract:
Extreme asset price movements appear to be more pronounced over time and have major consequences for an economy’s financial stability and monetary policies. This article investigates the extreme behaviour of equity market returns and quantifies the probabilities of these losses. Taking 14 major equity markets, the study illustrates similarities and divergences in the tail returns from around the world. To do so, it applies extreme value theory to equity indexes representing American, Asian and European markets. The article finds that all markets tail realisations are adequately modelled with the fat-tailed Fréchet distribution. Furthermore, tail realisations associated with the downside of a distribution are greater than those associated with the upside, and extreme returns for Asian markets are usually larger than their European and American counterparts.
Science Foundation Ireland
Embargo 18 months
http://hdl.handle.net/10197/3734
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Extreme risk in Asian equity markets
(2009)
Cotter, John
Extreme risk in Asian equity markets
(2009)
Cotter, John
Abstract:
Extreme price movements associated with tail returns are catastrophic for all investors and it is necessary to make accurate predictions of the severity of these events. Choosing a time frame associated with large financial booms and crises this paper investigates the tail behaviour of Asian equity market returns and quantifies two risk measures, quantiles and average losses, along with their associated average waiting periods. Extreme value theory using the Peaks over Threshold method generates the risk measures where tail returns are modelled with a fat-tailed Generalised Pareto Distribution. We find that lower tail risk measures are more severe than upper tail realisations at the lowest probability levels. Moreover, the Kuala Lumpar Composite exhibits the largest risk measures.
MPRA Paper No. 3536
http://hdl.handle.net/10197/1674
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Factors associated with the risk of, and animal-level response to, M. bovis in Irish cattle, 1993–98
(2017)
Martin, S. Wayne; O'Keeffe, James; White, Paul; Edge, Victoria; Collins, John D.
Factors associated with the risk of, and animal-level response to, M. bovis in Irish cattle, 1993–98
(2017)
Martin, S. Wayne; O'Keeffe, James; White, Paul; Edge, Victoria; Collins, John D.
Abstract:
Department of Agriculture, Food and the Marine
Teagasc
Deposited by bulk import
http://hdl.handle.net/10197/8862
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Family Structure and Risk Factors: an Investigation into Emotional and Behavioural Outcomes for Nine-Year-Olds.
(2012)
Lafferty, Zara
Family Structure and Risk Factors: an Investigation into Emotional and Behavioural Outcomes for Nine-Year-Olds.
(2012)
Lafferty, Zara
Abstract:
This study examined the relationship between family structure and risk factors for children’s emotional and behavioural outcomes at 9 years of age. Family structure in this study is defined as; married, separated, divorced, widowed and never married families. Three risk factors were identified from the literature; economic deprivation, maternal depression and life events. This study is a cross sectional quantitative analysis of the ‘Growing Up in Ireland’s’ child cohort (9 year olds) dataset. This is nationally representative sample of 9 year old children living in Ireland; the sample was collected through a two-stage, stratified random sampling approach. Of the 8,568 respondents in the sample, 8,209 meet the criterion of this study, which required that the respondents were female and had identified their marital status. The Strengths and Difficulties Questionnaire (SDQ) was used to measure emotional and behavioural outcomes. Annual income, the Basic Deprivation Scale, Centre for Ep...
https://arrow.dit.ie/aaschssldis/48
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Fgf receptor genes and breast cancer susceptibility: results from the breast cancer association consortium
(2018)
Agarwal, D; Pineda, S; Michailidou, K; Herranz, J; Pita, G; Moreno, L T; Alonso, M R; D...
Fgf receptor genes and breast cancer susceptibility: results from the breast cancer association consortium
(2018)
Agarwal, D; Pineda, S; Michailidou, K; Herranz, J; Pita, G; Moreno, L T; Alonso, M R; Dennis, J; Wang, Q; Bolla, M K; Meyer, K B; Menéndez-Rodríguez, P; Hardisson, D; Mendiola, M; González-Neira, A; Lindblom, A; Margolin, S; Swerdlow, A; Ashworth, A; Orr, N
Abstract:
Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium. Methods: Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results: Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European wom...
http://hdl.handle.net/10379/10128
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Financial Industry Ontologies for Risk and Regulation Data (FIORD): a position paper
(2014)
Koumpis, Adamantios
Financial Industry Ontologies for Risk and Regulation Data (FIORD): a position paper
(2014)
Koumpis, Adamantios
Abstract:
Conference paper
This paper presents a proposed approach to address risk andregulation management within the highly active and volatile financial domainby employing semantic based technologies within a collaborative networksenvironment. Firstly the problems and motivation are introduced, with accenton big data and high frequency trading issues that are creating major problemsto the current software systems. Secondly the state of the art on Big Data,Regulation and Risk Management are presented. Next the FIORD platformarchitecture is detailed and the envisioned approach explained. Finallyconclusions are presented where benefits for real time monitoring areemphasized so high frequency trading irregularities are detected in real time forthe benefit of involved financial institutions.
http://hdl.handle.net/10379/4104
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Fluoxetine and fractures after stroke: exploratory analyses from the FOCUS trial
(2019)
Dennis, Martin; Forbes, John F.; Graham,Catriona; Hackett, Maree L.; Hankey, Graeme J....
Fluoxetine and fractures after stroke: exploratory analyses from the FOCUS trial
(2019)
Dennis, Martin; Forbes, John F.; Graham,Catriona; Hackett, Maree L.; Hankey, Graeme J.; House, Allan; Lewis, Steff; Lundström, Erik; Sandercock, Peter; Mead, Gillian
Abstract:
Background and Purpose— The FOCUS trial (Fluoxetine or Control Under Supervision) showed that fluoxetine did not improve modified Rankin Scale scores (mRS) but increased the risk of fractures. We aimed to describe the fractures, their impact on mRS and factors associated with fracture risk. Methods— A United Kingdom, multicenter, parallel-group, randomized, placebo-controlled trial. Patients ≥18 years with a clinical stroke and persisting deficit assessed 2 to 15 days after onset were eligible. Consenting patients were allocated fluoxetine 20 mg or matching placebo for 6 months. The primary outcome was the mRS at 6 months and secondary outcomes included fractures. Results— Sixty-five of 3127 (2.1%) patients had 67 fractures within 6 months of randomization; 43 assigned fluoxetine and 22 placebo. Fifty-nine (90.8%) had fallen and 26 (40%) had fractured their neck of femur. The effect of fluoxetine on mRS (common odds ratio =0.951) was not significantly altered by excluding fracture p...
http://hdl.handle.net/10344/8585
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FM, Risk and Climate Change Adaptation
(2013)
Jones, Keith; Mulville, Mark; Brooks, Adele
FM, Risk and Climate Change Adaptation
(2013)
Jones, Keith; Mulville, Mark; Brooks, Adele
Abstract:
Improving the sustainability of built assets in the light of uncertain futures is a major challenge facing the Facilities Management profession. A changing climate poses significant challenges to the performance of built assets in-use and could potentially render many built assets prematurely obsolete. How business clients plan for such changes formed the focus of a research project undertaken by the authors. This paper presents the findings of a 12 month Action Research project that sought to identify the impact of future climate change on the performance of a new £75m education building over the first 60 years of operation. The Action Research project involved a series of meetings and workshops between the building’s design team (Architects, Engineers and Cost Consultants) and the Client’s Facilities Management (FM) Department where the impact that a range of future weather scenarios could have on the buildings performance in-use were evaluated. Technical and operational adaptatio...
https://arrow.dit.ie/beschreccon/117
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Genetic variation indnmt3band increased global dna methylation is associated with suicide attempts in psychiatric patients
(2018)
Murphy, T. M.; Mullins, N.; Ryan, M.; Foster, T.; Kelly, C.; McClelland, R.; O'Gra...
Genetic variation indnmt3band increased global dna methylation is associated with suicide attempts in psychiatric patients
(2018)
Murphy, T. M.; Mullins, N.; Ryan, M.; Foster, T.; Kelly, C.; McClelland, R.; O'Grady, J.; Corcoran, E.; Brady, J.; Reilly, M.; Jeffers, A.; Brown, K.; Maher, A.; Bannan, N.; Casement, A.; Lynch, D.; Bolger, S.; Buckley, A.; Quinlivan, L.; Daly, L.
Abstract:
Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt (SA) among patients with co-existing psychiatric illness. In addition, global DNA methylation levels [5-methyl cytosine (5-mC%)] between SA and psychiatric controls were quantified using the Methylflash Methylated DNA Quantification Kit. DNA was obtained from blood of 79 suicide attempters and 80 non-attempters, assessed for DSM-IV Axis I disorders. Functional SNPs were selected for each gene (DNMT1; n?=?7, DNMT3B; n?=?10), and genotyped. A SNP (rs2424932) residing in the 3' UTR of the DNMT3B gene was associated with SA compared with a non-attempter control group (P?=?0.001; Chi-squared test, Bonferroni adjusted P value?=?0.02). Moreover, haplotype analysis identified a DNMT3B haplotype which differed between cases and controls, however this association did...
http://hdl.handle.net/10379/13050
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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
(2018)
Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe...
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
(2018)
Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe; Lush, Michael J; Maranian, Mel J; Bolla, Manjeet K; Wang, Qin; Shah, Mitul; Perkins, Barbara J; Czene, Kamila; Eriksson, Mikael; Darabi, Hatef; Brand, Judith S; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Nielsen, Sune F; Rahman, Nazneen
Abstract:
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining similar to 14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 x 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be ...
http://hdl.handle.net/10379/12884
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Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study
(2019)
Stack, Austin G.; Johnson, Michelle Elizabeth; Blak, Betina; Klein, Alyssa; Carpenter, ...
Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study
(2019)
Stack, Austin G.; Johnson, Michelle Elizabeth; Blak, Betina; Klein, Alyssa; Carpenter, Lewis; Morlock, Robert; Maguire, Andrew R.; Parsons, Victoria L.
Abstract:
Objective Evaluate the association between gout and riskof advanced chronic kidney disease (CKD).Design Retrospective matched cohort study.Setting UK Clinical Practice Research Datalink.Participants The analysis included data for 68 897patients with gout and 554 964 matched patients withoutgout. Patients were aged ≥18 years, registered at UKpractices, had ≥12 months of clinical data and haddata linked with Hospital Episode Statistics. Patientswere excluded for history of advanced CKD, juvenilegout, cancer, HIV, tumour lysis syndrome, Lesch-Nyhansyndrome or familial Mediterranean fever.Primary and secondary outcome measures AdvancedCKD was defined as first occurrence of: (1) dialysis, kidneytransplant, diagnosis of end-stage kidney disease (ESKD)or stage 5 CKD (diagnostic codes in Read system orInternational Classification of Diseases, Tenth Revision);(2) estimated glomerular filtration rate (eGFR) <10 mL/min/1.73 m²; (3) doubling of serum creatinine frombaseline and (4) death ass...
http://hdl.handle.net/10344/8109
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