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Subject = temporal stability;
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Displaying Results 1 - 2 of 2 on page 1 of 1
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Composition and temporal stability of the gut microbiota in older persons
(2015)
Jeffery, Ian B.; Lynch, Denise B.; O'Toole, Paul W.
Composition and temporal stability of the gut microbiota in older persons
(2015)
Jeffery, Ian B.; Lynch, Denise B.; O'Toole, Paul W.
Abstract:
The composition and function of the human gut microbiota has been linked to health and disease. We previously identified correlations between habitual diet, microbiota composition gradients and health gradients in an unstratified cohort of 178 elderly subjects. To refine our understanding of diet–microbiota associations and differential taxon abundance, we adapted an iterative bi-clustering algorithm (iterative binary bclustering of gene sets (iBBiG)) and applied it to microbiota composition data from 732 faecal samples from 371 ELDERMET cohort subjects, including longitudinal samples. We thus identified distinctive microbiota configurations associated with ageing in both community and long-stay residential care elderly subjects. Mixed-taxa populations were identified that had clinically distinct associations. Microbiota temporal instability was observed in both community-dwelling and long-term care subjects, particularly in those with low initial microbiota diversity. However, the ...
http://hdl.handle.net/10468/9269
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Hemodynamic profile, compensation deficit, and ambulatory blood pressure
(2018)
Ottaviani, Cristina; Shapiro, David; Goldstein, Iris B.; James, Jack E.; Weiss, Robert
Hemodynamic profile, compensation deficit, and ambulatory blood pressure
(2018)
Ottaviani, Cristina; Shapiro, David; Goldstein, Iris B.; James, Jack E.; Weiss, Robert
Abstract:
This study hypothesized that physiologically grounded patterns of hemodynamic profile and compensation deficit would be superior to traditional blood pressure reactivity in the prediction of daily-life blood pressure. Impedance cardiography-derived measures and beat-to-beat blood pressure were monitored continuously in 45 subjects during baseline and four tasks. Ambulatory blood pressure measures were obtained combining data. from one work day and one off day. The mediating effects of gender and family history of hypertension were considered. Only gender was significantly associated with hemodynamic profile. Regression analysis indicated that typical reactivity measures failed to predict everyday life blood pressure. After controlling for gender and baseline blood pressure, hemodynamic patterns during specific tasks proved to be strong predictors, overcoming limitations of previous reactivity models in predicting real-life blood pressure.
http://hdl.handle.net/10379/9756
Displaying Results 1 - 2 of 2 on page 1 of 1
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Institution
NUI Galway (1)
University College Cork (1)
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Peer-reviewed (1)
Unknown (1)
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2018 (1)
2015 (1)
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