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Subject = thyroid-dysfunction;
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Effects of levothyroxine therapy on pregnancy outcomes in women with subclinical hypothyroidism
(2018)
Maraka, Spyridoula; Singh Ospina, Naykky M.; O'Keeffe, Derek T.; Rodriguez-Gutierr...
Effects of levothyroxine therapy on pregnancy outcomes in women with subclinical hypothyroidism
(2018)
Maraka, Spyridoula; Singh Ospina, Naykky M.; O'Keeffe, Derek T.; Rodriguez-Gutierrez, Rene; Espinosa De Ycaza, Ana E.; Wi, Chung-Il; Juhn, Young J.; Coddington, Charles C.; Montori, Victor M.; Stan, Marius N.
Abstract:
Background: Subclinical hypothyroidism (SCH) has been associated with increased risk of adverse pregnancy outcomes in some, but not all, studies. Uncertainty remains regarding the impact of levothyroxine (LT4) therapy on improving health outcomes in pregnant women with SCH. The objective of this study was to assess the potential benefits of LT4 therapy in pregnant women with SCH. Methods: The medical records were reviewed of pregnant women with SCH, defined as an elevated serum thyrotropin (TSH) of >2.5 mIU/L for the 1st trimester or >3 mIU/L for the 2nd and 3rd trimesters, but <= 10 mIU/L. Pregnant women were divided into two groups depending on whether they received LT4 (group A) or not (group B). Pregnancy loss and other pre-specified adverse outcomes were evaluated during follow-up. Results: There were 82 women in group A and 284 in group B. Group A had a higher body mass index (p = 0.04) and a higher serum TSH level (p < 0.0001) compa...
http://hdl.handle.net/10379/12641
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