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Displaying Results 1 - 25 of 105 on page 1 of 5
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3D Bioprinting of Anatomically Accurate Implants for Meniscus Tissue Engineering
(2020)
SCHEURER, STEFAN
3D Bioprinting of Anatomically Accurate Implants for Meniscus Tissue Engineering
(2020)
SCHEURER, STEFAN
Abstract:
Menisci are soft tissues essential for load bearing and stress distribution in the knee joint. Meniscal injuries are common in all age groups and can lead to degeneration of the joint. While currently available surgical debridement, meniscal repair and replacement strategies provide short-term relief, the ideal solution would be to facilitate meniscus regeneration. This has motivated increased interest in meniscus tissue engineering strategies to create more advanced cell-based implants for joint preservation. The overall aim of this thesis was to 3D bioprint a cell-laden and anatomically accurate engineered meniscus construct as an implant to replace meniscus tissue after a total or partial meniscectomy. Realizing this aim required the development of polymer scaffolds and bioinks with specific biomechanical properties and the potential to support fibro-cartilaginous tissue deposition by encapsulated cells. To produce scaffolds with biomechanical properties mimetic of the native men...
http://hdl.handle.net/2262/93964
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3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(2020)
SCHIPANI, ROSSANA
3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(2020)
SCHIPANI, ROSSANA
Abstract:
A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic joints. The objective of this thesis was to 3D bioprint cell-laden biomaterials with biomimetic mechanical properties as implants for regenerating large osteochondral defects. To this end, a finite element modelling (FEM) strategy was first developed to design the 3D printed polycaprolactone (PCL) networks with user-defined mechanical properties. These PCL networks were then combined with an alginate-gelatin methacryloyl (gelMA) interpenetrating network (IPN) hydrogel to develop 3D bioprinted constructs that were both mechanically functional and supportive of mesenchymal stromal cells (MSCs) chondrogenesis. When the IPN hydrogels were reinforced with a PCL network characterized by relatively high tension-compression nonlinearity, the resulting composites possesse...
http://hdl.handle.net/2262/93022
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A biomaterials approach to peripheral nerve repair
(2014)
Daly, William
A biomaterials approach to peripheral nerve repair
(2014)
Daly, William
Abstract:
Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm lead to debilitating and painful injuries for those afflicted. Treatments are limited and largely ineffective. The patient's own donor nerve (autograft) is the gold standard for repair but this treatment is largely unsuccessful, suffering from limited supply with donor site morbidity and pain. The use of hollow nerve guidance conduits (NGCs) is the current clinically approved alternative. However these have shown limited applicability in the clinic. Thus, the objective of this thesis was to improve and understand the use of these hollow NGCs and attempt to improve functional nerve regeneration using the concept of intraluminal guidance. Intraluminal guidance involves the incorporation of biomaterial structures (in this instance extruded collagen fibres) to repla...
http://hdl.handle.net/10379/4642
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A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering
(2013)
Lohfeld, Stefan; Tyndyk, M.A.; Cahill, S.; Flaherty, N.; Barron, Valerie; McHugh, Peter
A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering
(2013)
Lohfeld, Stefan; Tyndyk, M.A.; Cahill, S.; Flaherty, N.; Barron, Valerie; McHugh, Peter
Abstract:
Purpose:Selective laser sintering (SLS) is a rapid prototyping technique applied to produce tissue-engineering scaffolds from powder materials. The standard scanning technique, however, often produces struts of extensive thickness, which means fabrication of highly porous scaffolds with small overall dimensions is quite difficult. Nevertheless, this study aims to overcome this shortfall. Design/methodology/approach:To this end, three scanning methods were evaluated in terms of minimum feature size and freedom of design, using a test polyamide (PA) material. Polycaprolactone (PCL) was then employed to create highly porous 3D scaffolds using the preferred scanning method to produce thin struts.Findings:While in normal scanning mode some features were well above the laser spot diameter, strut thicknesses below the laser spot diameter were achieved when using the outline scan function for PA material. Those achieved for PCL were slightly higher and in the 500-800 µm range, with an ave...
http://hdl.handle.net/10379/3664
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A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
(2010)
Stops, Adam JF; Heraty, K B; Browne, M; O'Brien, Fergal J; McHugh, P E
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
(2010)
Stops, Adam JF; Heraty, K B; Browne, M; O'Brien, Fergal J; McHugh, P E
Abstract:
This article is also available at http://www.sciencedirect.com/
Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell responses are thus far underdeveloped. This investigation attempted to simulate cell responses in a collagen-glycosaminoglycan (CG) scaffold within a bioreactor. CG scaffold deformation was simulated using micro-computed tomography (CT) and an in-house finite element solver (FEEBE/linear). Similarly, the internal fluid velocities were simulated using the afore-mentioned microCT dataset with a computational fluid dynamics solver (ANSYS/CFX). From the ensuing cell-level mechanics, albeit octahedral shear strain or fluid velocity, the proliferation and differentiation of the representative cells were predicted from deterministic functions. Cell proliferation patterns concurred with previous experiments...
https://epubs.rcsi.ie/anatart/20
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A prediction of cell differentiation and proliferation within a collagen–glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow
(2018)
Stops, A.J.F.; Heraty, K.B.; Browne, M.; O'Brien, F.J.; McHugh, P.E.
A prediction of cell differentiation and proliferation within a collagen–glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow
(2018)
Stops, A.J.F.; Heraty, K.B.; Browne, M.; O'Brien, F.J.; McHugh, P.E.
http://hdl.handle.net/10379/14030
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Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
(2017)
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael J.; Lowery, Aoife J.
Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
(2017)
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael J.; Lowery, Aoife J.
Abstract:
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
http://hdl.handle.net/10344/6059
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Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
(2018)
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael; Lowery, Aoife
Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
(2018)
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael; Lowery, Aoife
Abstract:
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
http://hdl.handle.net/10379/13259
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Advanced Scaffold-Based Therapeutics for Peripheral Nerve Repair
(2018)
Lackington, William Arthur
Advanced Scaffold-Based Therapeutics for Peripheral Nerve Repair
(2018)
Lackington, William Arthur
Abstract:
<p>Despite the success of tissue engineered nerve guidance conduits (NGCs) for the treatment of small peripheral nerve injuries, autografts remain the clinical gold standard for larger injuries. Therefore, there is a substantial unmet clinical need for the development of more advanced NGC-based therapies for peripheral nerve repair. In this context, the overall objective of the research presented in this thesis was to develop an advanced NGC-based therapeutic for peripheral nerve repair, initially by engineering a neuroconductive and physicochemically optimized biphasic NGC, which was then functionalized for the controlled delivery of neurotrophic factors in order to accelerate nerve repair. Finally, this biphasic NGC was utilized as an innovative non-viral gene delivery platform in order to elicit a sustained but transient therapeutic response from endogenous cells.</p> <p>In Chapter 2, a biphasic NGC was successfully developed, combining a physicochemically optim...
https://epubs.rcsi.ie/phdtheses/241
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Advanced Strategies for Articular Cartilage Defect Repair
(2013)
Matsiko, Amos; Levingstone, Tanya J; O'Brien, Fergal
Advanced Strategies for Articular Cartilage Defect Repair
(2013)
Matsiko, Amos; Levingstone, Tanya J; O'Brien, Fergal
Abstract:
<p>This article is also available at <a href="http://www.mdpi.com/1996-1944/6/2/637">http://www.mdpi.com/1996-1944/6/2/637</a></p>
<p>Articular cartilage is a unique tissue owing to its ability to withstand repetitive compressive stress throughout an individual’s lifetime. However, its major limitation is the inability to heal even the most minor injuries. There still remains an inherent lack of strategies that stimulate hyaline-like articular cartilage growth with appropriate functional properties. Recent scientific advances in tissue engineering have made significant steps towards development of constructs for articular cartilage repair. In particular, research has shown the potential of biomaterial physico-chemical properties significantly influencing the proliferation, differentiation and matrix deposition by progenitor cells. Accordingly, this highlights the potential of using such properties to direct the lineage towards which s...
https://epubs.rcsi.ie/anatart/59
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An ex-vivo model to determine dental pulp responses to heat and light-curing of dental restorative materials
(2018)
Lynch, Christopher D.; Roberts, Jessica L.; Al-Shehri, Ali; Milward, Paul J.; Sloan, Al...
An ex-vivo model to determine dental pulp responses to heat and light-curing of dental restorative materials
(2018)
Lynch, Christopher D.; Roberts, Jessica L.; Al-Shehri, Ali; Milward, Paul J.; Sloan, Alastair J.
Abstract:
Aim: Based on histological studies from the 1960s, it is recommended that dental pulp temperature increases should not exceed 5.5 °C. However, no contemporary reliable models exist to explore the effects of heat on living dental pulp. The aim of this project was to develop a clinically valid model for studying temperature increases caused by three commonly-used light curing units (LCUs). Methods: Temperature increases caused by LCUs at varying exposure times and via various thicknesses of dentine were recorded using traditional approaches and an ex-vivo tooth slice model. Histomorphometric and immunohistochemical (IL-1β, HSP70, caspase-3) analysis was performed of the tooth slice model following varying exposure and culture times. Results: Reduced dentine thickness and increased exposure time led to increases in temperature. Whilst the majority of temperature increases recorded using the traditional approach (53 of 60) were greater than the recommended 5.5 °C, 52 of the 60 reference...
http://hdl.handle.net/10468/6746
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Analysis of osteogenesis on a novel collagen glycosaminoglycan scaffold- in vitro application for bone tissue engineering
(2010)
Keogh, Michael
Analysis of osteogenesis on a novel collagen glycosaminoglycan scaffold- in vitro application for bone tissue engineering
(2010)
Keogh, Michael
Abstract:
<p>Currently, there exists a need to develop new bone graft substitutes as an alternative to conventional autografting and allografting treatments due to disadvantages such as cost, scarcity of tissue, multiple surgical procedures and the risk of infection. Tissue engineering provides an alternative solution and relies extensively on the use of porous scaffolds to provide the appropriate environment for the regeneration of tissues and organs. These scaffolds are typically seeded with cells and occasionally growth factors or subjected to biophysical stimuli in the form of a bioreactor and are either cultured <em>in vitro </em>to synthesise tissues which can then be implanted into an injured site or are implanted directly into the injured site and through the body's own systems, regeneration of tissues or organs is induced <em>in vivo. </em>In our laboratory, we use a type 1 collagen glycosaminoglycan (CG) scaffold for tissue engineering applications...
https://epubs.rcsi.ie/phdtheses/30
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Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
(2019)
Kelly, Daniel; Freeman, F.E.; Browe, D.C.; D?az-Payno, P.J.; Nulty, J.; Von Euw, S.; Gr...
Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
(2019)
Kelly, Daniel; Freeman, F.E.; Browe, D.C.; D?az-Payno, P.J.; Nulty, J.; Von Euw, S.; Grayson, W.L.
Abstract:
Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising strategy to achieve this as it allows the control over scaffold pore size, porosity and interconnectivity. Thus, the aim of the present study was to integrate distinct biofabrication strategies to develop a multiscale porous scaffold that was not only mechanically functional at the time of implantation, but also facilitated rapid vascularisation and provided stem cells with appropriate cues to enable their differentiation into osteoblasts. To achieve this, polycaprolactone (PCL) was functionalised with decellularised bone extracellular matrix (ECM), to produce osteoinductive filaments for 3D printing. The addition of bone ECM to the PCL not only increased the mechanical properties of the resulting scaffold, but also increased cellular attachment and enhanced osteo...
http://hdl.handle.net/2262/91276
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Biomaterials and scaffolds for tissue engineering
(2011)
O'Brien, Fergal J
Biomaterials and scaffolds for tissue engineering
(2011)
O'Brien, Fergal J
Abstract:
<p>NOTICE: this is the author’s version of a work that was accepted for publication in Materials Today. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Today, 14, 3, (March 2011). http://www.materialstoday.com/</p>
<p>Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. This article describes the functional requirements, and types, of materials used in developing state...
https://epubs.rcsi.ie/anatart/38
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Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration - Implications for Cell-Based Regenerative Therapy
(2016)
Buckley, Conor
Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration - Implications for Cell-Based Regenerative Therapy
(2016)
Buckley, Conor
http://hdl.handle.net/2262/80186
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Boron nitride nanotube addition enhances the crystallinity and cytocompatibility of PVDF-TrFE
(2019)
Poudel, Anup; Fernandez, Marc A.; Tofail, Syed A.M.; Biggs, Manus J.
Boron nitride nanotube addition enhances the crystallinity and cytocompatibility of PVDF-TrFE
(2019)
Poudel, Anup; Fernandez, Marc A.; Tofail, Syed A.M.; Biggs, Manus J.
Abstract:
Analysis of the cellular response to piezoelectric materials has been driven by the discovery that many tissue components exhibit piezoelectric behavior ex vivo. In particular, polyvinylidene fluoride and the trifluoroethylene co-polymer (PVDF-TrFE) have been identified as promising piezo and ferroelectric materials with applications in energy harvesting and biosensor devices. Critically, the modulation of the structural and crystalline properties of PVDF-TrFE through annealing processes and the addition of particulate or fibrous fillers has been shown to modulate significantly the materials electromechanical properties. In this study, a PVDF-TrFE/boron-nitride nanotube composite was evaluated by modulated differential scanning calorimetry to assess the effects of boron nitride nanotube addition and thermal annealing on the composite structure and crystal behavior. An increased beta crystal formation [f(b) = 0.71] was observed following PVDF-TrFE annealing at the first crystallizat...
http://hdl.handle.net/10344/7872
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Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints
(2018)
Levingstone, Tanya J.; Ramesh, Ashwanth; Brady, Robert T.; Brama, Pieter A.J.; Kearney,...
Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints
(2018)
Levingstone, Tanya J.; Ramesh, Ashwanth; Brady, Robert T.; Brama, Pieter A.J.; Kearney, Clodagh; Gleeson, John P.; O'Brien, Fergal J.
http://hdl.handle.net/10379/12433
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Cell-scaffold interactions in the bone tissue engineering triad.
(2013)
Murphy, Ciara M; O'Brien, Fergal J; Little, David G; Schindeler, Aaron
Cell-scaffold interactions in the bone tissue engineering triad.
(2013)
Murphy, Ciara M; O'Brien, Fergal J; Little, David G; Schindeler, Aaron
Abstract:
<p>This article is available with the kind permission of full reproduction from eCM journal (www.ecmjournal.org). Founded by scientists for the benefit of Science rather than profit.</p> <p>Link to, <a href="http://www.ecmjournal.org/journal/papers/vol026/vol026a09.php">http://www.ecmjournal.org/journal/papers/vol026/vol026a09.php</a></p> <p><img alt="" src="http://www.ecmjournal.org/pubmed/ecm_logo.gif" /></p>
<p>Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver them--otherwise known as the tissue engineering triad. This review will discuss the roles of these fundamental components with a specific focus on the interaction between cell behaviour and scaffold st...
https://epubs.rcsi.ie/anatart/61
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Cell-seeded decellularised extracellular matrices as an advanced approach for tissue engineering
(2009)
Piterina, Anna Valentinova; Davis, Laura M.; Meaney, Claire L.; Cloonan, Aidan J.; Wals...
Cell-seeded decellularised extracellular matrices as an advanced approach for tissue engineering
(2009)
Piterina, Anna Valentinova; Davis, Laura M.; Meaney, Claire L.; Cloonan, Aidan J.; Walsh, Michael T.; McGloughlin, Timothy M.
Abstract:
Development and optimisation of therapeutic applications using biological scaffolds composed of naturally occurring extracellular matrix (ECM) have received significant attention in the field of tissue engineering. Histological and molecular investigations combined with comprehensive electron microscopy have shown that decellularised matrices from animal sources may vary in structure and biochemical properties. The source (bladder or small intestine submucosa), species, age of animal, and type of preparation of these matrices may contribute to the unique biophysical properties of the delivered product. Comparison of the thickness, topography, porosity and biomechanical properties of these matrices are presented. Vascular cell adhesion, migration and proliferation, and cell ingrowths on scaffold matrices were analysed using fluorescent labelling and laser confocal microscopy. ECM is shown to be a promising material for vascular tissue engineering and supports the growth, proliferatio...
http://hdl.handle.net/10344/1267
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Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(2020)
MAHON, OLWYN
Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(2020)
MAHON, OLWYN
Abstract:
Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from an acute traumatic injury to the knee or an underlying disorder of the bone. If left untreated, localised OCDs can become widespread and often progress to more severe damage, as is the case in Osteoarthritis (OA). It is now widely accepted that cartilage damage in OA is associated with inflammation and a number of ?damage? or ?danger? associated molecules have been identified that contribute to this phenotype. They include hyaluronic acid fragments, basic calcium phosphate (BCP) crystals and members of the S100 family of proteins. As joint damage progresses, total joint replacement (TJR) is required to relieve pain and restore joint function, however TJRs themselves are associated with long-term complications such as periprosthetic osteolysis (PO) which is driven by ...
http://hdl.handle.net/2262/92807
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Characterization of extracellular matrix modified poly(?-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)
Ahearne, Mark; Fern?ndez-P?rez, Julia; Kador, Karl E.; Lynch, Amy P.
Characterization of extracellular matrix modified poly(?-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)
Ahearne, Mark; Fern?ndez-P?rez, Julia; Kador, Karl E.; Lynch, Amy P.
Abstract:
Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties and degradation resistance; while synthetic polymers have good mechanical properties but do not contain biochemical molecules normally found in the real tissue. In addition, both fiber orientation and composition play a key role in dictating cell behavior within a scaffold. In this study, the effect on corneal stromal cells of adding decellularized corneal extracellular matrix (ECM) to an electrospun polymer with differing fiber organizations was explored. Electrospun matrices were generated using polycaprolactone (PCL) and PCL combined with ECM and electrospun into random, radial and perpendicularly aligned fiber scaffolds. Human corneal stromal cells were seeded onto these scaffolds and the effect of composition and orientation on the cells phenotype was asse...
http://hdl.handle.net/2262/90962
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Chitosan for gene delivery and orthopedic tissue engineering applications.
(2013)
Raftery, Rosanne; O'Brien, Fergal; Cryan, Sally-Ann
Chitosan for gene delivery and orthopedic tissue engineering applications.
(2013)
Raftery, Rosanne; O'Brien, Fergal; Cryan, Sally-Ann
Abstract:
<p>This article is also available at <a href="http://www.mdpi.com/1420-3049/18/5/5611">http://www.mdpi.com/1420-3049/18/5/5611</a></p>
<p>Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated with viral and synthetic non-viral gene delivery approaches. One natural polymer which has generated interest as a gene delivery vector is chitosan. Chitosan is biodegradable, biocompatible and non-toxic. Much of the appeal of chitosan is due to the presence of primary amine groups in its repeating units which become protonated in acidic conditions. This property makes it a promising candidate for non-viral gene de...
https://epubs.rcsi.ie/anatart/58
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Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration
(2015)
Freeman, Fiona
Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration
(2015)
Freeman, Fiona
Abstract:
Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and physical conditions. However, these approaches are limited and as such are not yet widely used for clinical treatment of large bone defects. The main limitations include degradation of the tissue engineered constructs, due to lack of vascularisation, and a lack of mechanical integrity to fulfil loading bearing functions. Recent studies have suggested that in vitro approaches, which mimic certain aspects of bone formation during embryogenesis (i.e. the endochondral ossification process), can promote mineralisation and vascularisation to a certain extent both in vitro and in vivo. However, in vivo endochondral ossification relies on the production of a cartilage template and the invasion of a vascular network into this template, and both events must occur before bone tiss...
http://hdl.handle.net/10379/5359
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Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials
(2016)
Coakley, Daniel Nicholas Martin; Shaikh, F.M; O'Sullivan, K; Kavanagh, Eamon G.; G...
Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials
(2016)
Coakley, Daniel Nicholas Martin; Shaikh, F.M; O'Sullivan, K; Kavanagh, Eamon G.; Grace, Pierce A.; Walsh, Stewart R.; McGloughlin, Timothy M.
Abstract:
Introduction Existing synthetic vascular grafts have unacceptably high failure rates when replacing small diameter infrapopliteal vessels [1]. The lack of a confluent endothelial lining is repeatedly cited as the most common cause of conduit failure [2, 3].
http://hdl.handle.net/10344/4888
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Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
(2014)
KELLY, DANIEL; O'BRIEN, FERGAL; CUNNIFFE, GR?INNE
Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
(2014)
KELLY, DANIEL; O'BRIEN, FERGAL; CUNNIFFE, GR?INNE
Abstract:
Abstract: The objective of this study was to develop a scaffold derived from cartilaginous extracellular matrix (ECM) that could be used as a growth factor delivery system to promote chondrogenesis of stem cells. Dehyd rothermal crosslinked scaffolds were fabricated using a slurry of homogenized porcine articular cartilage, which were then seeded with human infrapatellar fat pad derived stem cells (FPSCs). It was found that these ECM derived scaffolds promoted superior c hondrogenesis of FPSCs when the constructs were additionally stimulated with transforming growth factor (TGF) - ?3. Cell mediated contraction of the scaffold was observed, which could be limited by the additional use of 1 - Ethyl - 3 - 3dimethyl aminopropyl carbod iimide (EDAC) crosslinking without suppressing cartilage specific matrix accumulation within the construct. To further validate the utility of the ECM derived scaffold, we next compared its chondro - permissive properties to a biomimetic collagen - hyaluro...
http://hdl.handle.net/2262/72871
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