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Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation
Singh, Ishwar; Vyle, Joseph S.; Heaney, Frances
Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.
Keyword(s): Chemistry; copper-free click chemistry; solid-phase; oligonucleotide conjugation; catalyst
Publication Date:
2009
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345
Publisher(s): Royal Society of Chemstry
File Format(s): application/pdf
Related Link(s): http://eprints.maynoothuniversity.ie/2706/1/FH_Click_Chemistry.pdf
First Indexed: 2014-09-20 05:04:49 Last Updated: 2017-04-26 00:00:32