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How metabolism generates signals during innate immunity and inflammation
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE
The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune response is well documented. Exciting new evidence is emerging with regard to their role in the regulation of metabolism and the activation of inflammatory pathways during the progression of metabolic disorders such as type 2 diabetes and atherosclerosis. The proinflammatory cytokine IL-1? appears to play a central role in these disorders. There is also evidence that metabolites such as NAD+ (acting via deacetylases such as SIRT1 and SIRT2) and succinate (which regulates hypoxia-inducible factor 1?) are signals that regulate innate immunity. In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1?. These observations cast new light on the role of metabolism during host defense and inflammation.
Keyword(s): Signal Transduction; Metabolism,; Metabolic Regulation; Metabolic Diseases; Innate Immunity,; Inflammation; Immunology, Inflammation & Infection
Publication Date:
2013
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, 32, 2013, 22893-22898
First Indexed: 2014-12-11 05:36:03 Last Updated: 2020-10-30 07:48:16