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Biology using engineering tools: The negative feedback amplifier
Birtwistle, Marc R.; Kolch, Walter
Negative feedback is an ubiquitous feature of biological networks. Recent work from Sturm and colleaguespresents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer. SFI Grant No. 06/CE/B1129, and M.R.B. acknowledges a Marie Curie International Incoming Fellowship (236758) and an EMBO longterm fellowship (ALTF 815-2010). Deposited by bulk import
Keyword(s): negative feedback; signal transduction; quantitative modeling; mitogen activated protein kinase; spatiotemporal dynamics
Publication Date:
2013
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): Landes Bioscience
First Indexed: 2015-02-04 05:43:09 Last Updated: 2018-10-11 16:42:24