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Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
Kolch, Walter; Pitt, Andrew
Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)–ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics. SFI grant No. 06/CE/B1129 (WK) and BBSRC and EPSRC via the RASOR project BB/C511572/1 Deposited by bulk import
Keyword(s): Functional proteomics; signal transduction pathways; cancer; epidermal growth factor receptor (EGFR); ERK; breakpoint cluster region (BCR)–ABL1
Publication Date:
2013
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): Nature Publishing Group
First Indexed: 2015-02-04 05:43:11 Last Updated: 2018-10-11 16:34:58