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Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
KEANE, JOSEPH; PALSSON, EVA; O'NEILL, LUKE; SHEEDY, FREDERICK
TLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify PKM2 as a critical modulator of IL-1 b production and the Warburg effect in LPS-activated macrophages, highlighting it as a target in cancer and inflammation
Keyword(s): TLR4-activated macrophages; Immunology, Inflammation & Infection; Immune system; Immunology, Immunotherapy; Molecular Biology
Publication Date:
2015
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, 1, 2015, 65-80
First Indexed: 2015-03-07 05:50:24 Last Updated: 2020-10-30 07:34:13