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Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation
BRACKEN, ADRIAN
The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.
Keyword(s): BONE-MARROW-CELLS; HUMAN BREAST-TUMORS; LONG NONCODING RNAS; GENOME-WIDE ANALYSIS; HEMATOPOIETIC STEM-CELLS; ACUTE PROMYELOCYTIC LEUKEMIA; TRANSCRIPTION FACTOR-BINDING; CELL SELF-RENEWAL; TUMOR-SUPPRESSOR GENE; ACUTE MYELOID-LEUKEMIA; Cancer; Genes & Society
Publication Date:
2009
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): Brien GL, Bracken AP., Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation, Seminars in Cell and Developmental Biology, 20, 7, 2009, 835 - 841
First Indexed: 2015-05-07 05:35:07 Last Updated: 2018-07-27 06:33:19