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Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.
Aherne, Sinéad T; Madden, Stephen F; Hughes, David J; Pardini, Barbara; Naccarati, Alessio; Levy, Miroslav; Vodicka, Pavel; Neary, Paul; Dowling, Paul; Clynes, Martin
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p> <p><strong>BACKGROUND:</strong> Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups.</p> <p><strong>METHODS:</strong> The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues.</p> <p><strong>RESULTS:</strong> High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In addition, the altered expression of miR-34a and miR-150 in an independent public dataset of forty CRC samples and paired normal tissues was confirmed.</p> <p><strong>CONCLUSION:</strong> We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups.</p>
Keyword(s): Colorectal cancer; Circulating miRNAs; miR-34a; miR-150; miR-923; Physics; Physiology
Publication Date:
2015
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Aherne ST, Madden SF, Hughes DJ, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Dowling P, Clynes M12. Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. BMC Cancer. 2015;15(1):329
Publisher(s): Biomed Central
File Format(s): application/pdf
Related Link(s): http://epubs.rcsi.ie/physiolart/58
First Indexed: 2015-07-31 15:34:28 Last Updated: 2019-02-06 07:21:22