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Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach.
Harney, Donal F; Butler, Ryan K; Edwards, Richard J
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p> <p>BACKGROUND: Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s) for this phosphorylation event.</p> <p>RESULTS: A combined bioinformatics approach of motif prediction and evolutionary and structural analyses identified tyrosines163 and 1856 of the skeletal muscle heavy chain as the leading candidate for the sites of insulin-mediated tyrosine phosphorylation.</p> <p>CONCLUSION: Our work is suggestive that tyrosine phosphorylation of myosin heavy chain, whether in skeletal muscle or in platelets, is a significant event that may initiate cytoskeletal reorganization of muscle cells and platelets. Our studies provide a good starting point for further functional analysis of MHC phosphor-signalling events within different cells.</p>
Keyword(s): Algorithms; Amino Acid Sequence; Animals; Cell Differentiation; Chickens; Computational Biology; Humans; Molecular Sequence Data; Muscle; Skeletal; Myosin Heavy Chains; Phosphorylation; Phosphotyrosine; Phylogeny; Sequence Homology; Amino Acid; Life Sciences
Publication Date:
2005
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Harney DF, Butler RK, Edwards RJ. Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach. Theoretical Biology & Medical Modelling. 2005;2:12.
File Format(s): application/pdf
Related Link(s): http://epubs.rcsi.ie/mctart/55
First Indexed: 2015-07-31 15:36:08 Last Updated: 2018-02-13 07:21:04