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The meniscus, calcification and osteoarthritis: a pathologic team.
MacMullan, Paul A; McCarthy, Geraldine M
This article is available at Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable.
Keyword(s): Calcinosis; Calcium; Calcium Phosphates; Calcium Pyrophosphate; Cartilage; Articular; Crystallization; Humans; Osteoarthritis; Life Sciences
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): MacMullan PA, McCarthy GM. The meniscus, calcification and osteoarthritis: a pathologic team. Arthritis Research & Therapy. 2010;12(3):116.
File Format(s): application/pdf
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First Indexed: 2015-07-31 15:36:12 Last Updated: 2018-02-13 07:20:57