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Chemotherapy induced peripheral neuropathy: the modified total neuropathy score in clinical practice.
Vasquez, Sine; Guidon, Marie; McHugh, E; Lennon, Olive; Grogan, Liam; Breathnach, Oscar S
<p>This article is also available at <a href=""></a> or <a href=""></a></p> <p><strong>BACKGROUND:</strong> Chemotherapy-induced peripheral neuropathy (CIPN) is a common, potentially reversible side effect of some chemotherapeutic agents. CIPN is associated with decreased balance, function and quality of life (QoL). This association has to date been under-investigated.</p> <p><strong>AIMS:</strong> To profile patients presenting with CIPN using the modified Total Neuropathy Score (mTNS) in this cross-sectional study and to examine the relationship between CIPN (measured by mTNS) and indices of balance, quality of life (QoL) and function.</p> <p><strong>METHODS:</strong> Patients receiving neurotoxic chemotherapy regimens were identified using hospital databases. Those who did not have a pre-existing neuropathy were invited to complete mTNS, Berg Balance Scale (BBS), timed up and go (TUG), and FACT-G QoL questionnaire. mTNS scores were profiled and also correlated with BBS, TUG and FACT-G using Spearmans correlation coefficient.</p> <p><strong>RESULTS:</strong> A total of 29 patients undergoing neurotoxic chemotherapy regimens were tested. The patients mTNS scores ranged between 1 and 12 (median = 5), indicating that all patients had clinical evidence of neuropathy on mTNS. No significant correlations were found between mTNS and BERG (r = -0.29), TUG (r = 0.14), or FACT-G (r = 0.05).</p> <p><strong>CONCLUSIONS:</strong> This study found a high prevalence of CIPN in patients treated with neurotoxic chemotherapy regimens. The mTNS provided a clinically applicable, sensitive screening tool for CIPN which could prove useful in clinical practice. mTNS did not correlate with BBS, TUG or FACT-G in this sample, possibly due to relatively mild levels of CIPN and consequent subtle impairments which were not adequately captured by gross functional assessments.</p>
Keyword(s): Peripheral Neuropathy; Neurotoxic; Physiotherapy; chemotherapy; Function; Medicine and Health Sciences; Rehabilitation and Therapy
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Vasquez S, Guidon M, McHugh E, Lennon O, Grogan L, Breathnach OS. Chemotherapy induced peripheral neuropathy: the modified total neuropathy score in clinical practice. Irish Journal of Medical Science. 2014;183(1):53-8.
Publisher(s): Springer
File Format(s): application/pdf
Related Link(s):
First Indexed: 2015-07-31 15:36:44 Last Updated: 2019-01-31 07:15:29