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Towards the Asymmetric Synthesis of 1,2-Oxazines |
Piras, Linda
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<p>The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity.</p>
<p>In Chapter 2 the synthesis of cycloadducts 2.24 was attempted starting fiom acyl nitroso species 2.2.</p>
<p>In Chapter 3 a novel route to alkene-functionalised monobactams was developed and their potential in diversity oriented synthesis is still in progress.</p>
<p>In Chapter 4 we have described a good enantioselective Michael-initiated ring closure (MIRC) reaction of 2,3 -substituted- 1,1 -cyclopropanediesters under operationally simple conditions and mild PTC catalysis. The study delivers a class of novel enantiopure Michael adducts which could serve as valuable building blocks and as templates of high potential synthetic utility.</p> <p>A thesis submitted to the Royal College of Surgeons in Ireland for the degree of Doctor of Philosophy from the National University of Ireland in 2010.</p>
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Keyword(s):
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Chemistry; Pharmaceutical; Oxazines; Medicine and Health Sciences |
Publication Date:
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2010 |
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Type:
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Doctoral thesis |
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Peer-Reviewed:
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No |
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Institution:
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Royal College of Surgeons in Ireland |
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Citation(s):
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Piras L. Towards the Asymmetric Synthesis of 1,2-Oxazines [PhD Thesis]. Dublin: Royal College of Surgeons in Ireland; 2010 |
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Supervisor(s):
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Dr Mauro Adamo
Dr Francesco Fini |
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Related Link(s):
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http://epubs.rcsi.ie/phdtheses/27/ |
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First Indexed:
2015-07-31 15:37:14 Last Updated:
2018-02-13 07:19:02 |
