Institutions | About Us | Help | Gaeilge
rian logo

Go Back
Towards the Asymmetric Synthesis of 1,2-Oxazines
Piras, Linda
<p>The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity.</p> <p>In Chapter 2 the synthesis of cycloadducts 2.24 was attempted starting fiom acyl nitroso species 2.2.</p> <p>In Chapter 3 a novel route to alkene-functionalised monobactams was developed and their potential in diversity oriented synthesis is still in progress.</p> <p>In Chapter 4 we have described a good enantioselective Michael-initiated ring closure (MIRC) reaction of 2,3 -substituted- 1,1 -cyclopropanediesters under operationally simple conditions and mild PTC catalysis. The study delivers a class of novel enantiopure Michael adducts which could serve as valuable building blocks and as templates of high potential synthetic utility.</p> <p>A thesis submitted to the Royal College of Surgeons in Ireland for the degree of Doctor of Philosophy from the National University of Ireland in 2010.</p>
Keyword(s): Chemistry; Pharmaceutical; Oxazines; Medicine and Health Sciences
Publication Date:
Type: Doctoral thesis
Peer-Reviewed: No
Institution: Royal College of Surgeons in Ireland
Citation(s): Piras L. Towards the Asymmetric Synthesis of 1,2-Oxazines [PhD Thesis]. Dublin: Royal College of Surgeons in Ireland; 2010
Supervisor(s): Dr Mauro Adamo
Dr Francesco Fini
Related Link(s):
First Indexed: 2015-07-31 15:37:14 Last Updated: 2018-02-13 07:19:02