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Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
Matsiko, Amos; Levingstone, Tanya J; Gleeson, John P; O'Brien, Fergal
<p>The original article is available at onlinelibrary.wiley.com</p> <p>Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.</p>
Keyword(s): Articular cartilage; collagen-based scaffolds; growth factor delivery; mesenchymal stem cells; transforming growth factor-beta 3; Anatomy
Publication Date:
2015
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Matsiko A, Levingstone TJ, Gleeson JP, O'Brien FJ. Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Advanced Healthcare Materials. 2015;4(8):1175-9.
Publisher(s): John Wiley & Sons
File Format(s): application/pdf
Related Link(s): http://epubs.rcsi.ie/anatart/80
First Indexed: 2015-10-14 06:15:13 Last Updated: 2018-02-13 07:18:32