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Nanomedicine applied to translational oncology: A future perspective on cancer treatment.
The high global incidence of cancer is associated with high rates of mortality and morbidity worldwide. By taking advantage of the properties of matter at the nanoscale, nanomedicine promises to develop innovative drugs with greater efficacy and less side effects than standard therapies. Here, we discuss both clinically available anti-cancer nanomedicines and those en route to future clinical application. The properties, therapeutic value, advantages and limitations of these nanomedicine products are highlighted, with a focus on their increased performance versus conventional molecular anticancer therapies. The main regulatory challenges towards the translation of innovative, clinically effective nanotherapeutics are discussed, with a view to improving current approaches to the clinical management of cancer. Ultimately, it becomes clear that the critical steps for clinical translation of nanotherapeutics require further interdisciplinary and international effort, where the whole stakeholder community is involved from bench to bedside.
Keyword(s): nanomedicine regulation; nanodrug design; translational oncology; Cancer; Nanoscience & Materials; CANCER TREATMENT; Cancer Molecular Diagnostics; In vitro alternatives to animal studies; NanoMedicine; Nanomedicine; ONCOLOGY; THERAPEUTICS; Therapeutic and Clinical oncology; nanomedicine; theranostics
Publication Date:
Type: Review
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): Bregoli L, Movia D, Gavigan-Imedio JD, Lysaght J, Reynolds J, Prina-Mello A, Nanomedicine applied to translational oncology: A future perspective on cancer treatment., Nanomedicine : nanotechnology, biology, and medicine, 12, 1, 2016
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First Indexed: 2015-10-30 05:44:16 Last Updated: 2017-05-09 06:23:13