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Development of a microfluidic device and imaging system for the monitoring of anti-platelet therapy
McCluskey, Peter M.
This work details the development of two distinct prototype point-of-care diagnostic systems to be used to determine the ecacy of anti-platelet ther- apies. Novel micro uidic chips were designed for each system, to enable the on-chip testing of multiple anti-platelet therapies. The prototypes work with whole blood and integrate with a new detection method used to de- termine the percentage of platelets adhered to an array of brinogen spots. The system uses customised image analysis software to objectively quantify single platelet binding events from a single blood sample, without the need to add any form of labelling to the blood. The system was validated by comparing the percentage of platelets adhered from `normal' blood samples compared to samples treated with an established platelet therapy. These treatments inhibit a specic receptor on the platelet surface, thus inter- fering with stable adhesion to brinogen, rendering platelets \less sticky". This prototype point-of-care device could allow for the automated testing of large numbers of patient samples, potentially diagnosing individuals at risk of suering a cardiovascular event or undiagnosed bleeding disorder.
Keyword(s): Biomedical engineering; Platelets; MEMS
Publication Date:
Type: Other
Peer-Reviewed: Unknown
Language(s): English
Contributor(s): Corcoran, Brian; Kent, Nigel
Institution: Dublin City University
Citation(s): McCluskey, Peter M. (2015) Development of a microfluidic device and imaging system for the monitoring of anti-platelet therapy. PhD thesis, Dublin City University.
Publisher(s): Dublin City University. School of Mechanical and Manufacturing Engineering
File Format(s): application/pdf
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First Indexed: 2015-11-26 05:05:11 Last Updated: 2019-02-09 06:21:22