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A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
Santos-Mart?nez, Mar?a Jos?
THESIS 9208 Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly quantified using methods and devices that assess platelet aggregation under static conditions in macroscale. However, current devices neither mimic the conditions found in human microvasculature nor detect microaggregates. Aim: To provide pharmacological characteristics of a novel method of flow- induced platelet aggregation using a commercially available nanoscale resolution device, the Quartz Crystal Microbalance with Dissipation (Q-Sense? E4).
Keyword(s): Pharmacy, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2009
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Mar?a Jos? Santos-Mart?nez, 'A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009, pp 157
Publisher(s): Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
Supervisor(s): Radomski, Marek W.
First Indexed: 2016-12-06 07:36:22 Last Updated: 2019-10-04 06:22:00