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The synthesis and chemistry of macrolactones
Cook, Lawrence D.
THESIS 10545 The work herein presented is an investigation into the methodology of macrolactonisation via an intramolecular acylative cleavage of a tetrahydrofuran ring. The thesis is divided into three Chapters: an introduction outlining the history and biological role of macrolactones, and the techniques currently being exploited in their synthesis; an improvement upon the technique of macrolactonisation via intramolecular acylative cleavage of tetrahydrofuran rings; and progress towards the total synthesis of the naturally occurring macrolactone curvularin.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Lawrence D. Cook, 'The synthesis and chemistry of macrolactones', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2014, pp 315
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Grayson, David
First Indexed: 2017-02-24 06:41:45 Last Updated: 2017-02-24 06:41:45