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Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
Cooke, Niamh M; Spillane, Cathy D; Sheils, Orla; O'Leary, John; Kenny, Dermot
Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level.
Publication Date:
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: Lenus
Publisher(s): BioMed Central
First Indexed: 2017-03-09 05:53:06 Last Updated: 2017-05-12 08:21:35