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A study on novel pyrazine-substituted dithiolene complexes as synthetic models for molybdenum cofactor and facile molybdenum mediated unexpected formation of pentathiepins
Zubair, Muhammad
THESIS 10522 In the present study, pyrazine (3 and 12) and quinoxaline (4 and 9-11) based compounds were synthesised as precursors for the synthetic analogues of MPT in MoCo. During the attempts to synthesise target model complexes, an unexpected formation of quinoxaline-derived pentathiepin (15) was observed. This by chance invented method for preparation of pentathiepin was optimised and then used to synthesise a series of other pentathiepin derivatives (16-18). Further on, a study has been made with regard to evaluate the influence of different substituents on the biological properties of these compounds. All pentathiepin derivatives (15-18) exhibited promising DNA binding properties as a minor groove binding agents and remarkable therapeutic activities.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2014
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Muhammad Zubair, 'A study on novel pyrazine-substituted dithiolene complexes as synthetic models for molybdenum cofactor and facile molybdenum mediated unexpected formation of pentathiepins', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2014, pp 207
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Schulzke, Carola
Baker, Robert
First Indexed: 2017-07-05 05:36:16 Last Updated: 2017-07-05 05:36:16