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?-Lactalbumin-oleic acid complex : structure function dynamics |
Xie, Yongjing
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THESIS 10852 Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogues are partially unfolded protein-oleic acid complexes that exhibit selective tumoricidal activity normally absent in the native protein itself, in order to understand the nature of the interaction between a-lactalbumin and oleic acid moieties, charge-specific chemical modifications of lysine residues involving citraconylation, acetylation and guanidination were employed and the biophysical and biological properties of the wild type and chemically modified bovine a-lactalbumin-oleic acid complexes were characterized.
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Keyword(s):
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Biochemistry & Immunology, Ph.D.; Ph.D. Trinity College Dublin |
Publication Date:
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2015 |
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Type:
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Doctoral thesis |
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Peer-Reviewed:
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Unknown |
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Language(s):
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English |
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Institution:
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Trinity College Dublin |
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Citation(s):
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Yongjing Xie, '?-Lactalbumin-oleic acid complex : structure function dynamics', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 289 |
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Publisher(s):
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Trinity College (Dublin, Ireland). School of Biochemistry and Immunology |
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Supervisor(s):
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Hun Mok, Kenneth |
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First Indexed:
2017-07-06 05:43:41 Last Updated:
2017-07-06 05:43:41 |
