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?-Lactalbumin-oleic acid complex : structure function dynamics
Xie, Yongjing
THESIS 10852 Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogues are partially unfolded protein-oleic acid complexes that exhibit selective tumoricidal activity normally absent in the native protein itself, in order to understand the nature of the interaction between a-lactalbumin and oleic acid moieties, charge-specific chemical modifications of lysine residues involving citraconylation, acetylation and guanidination were employed and the biophysical and biological properties of the wild type and chemically modified bovine a-lactalbumin-oleic acid complexes were characterized.
Keyword(s): Biochemistry & Immunology, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Yongjing Xie, '?-Lactalbumin-oleic acid complex : structure function dynamics', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 289
Publisher(s): Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
Supervisor(s): Hun Mok, Kenneth
First Indexed: 2017-07-06 05:43:41 Last Updated: 2018-08-24 06:47:12