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A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation
Ivanov, Ivaylo P.; Atkins, John F.; Michael, Antony J.
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
Keyword(s): S-adenosylmethionine decarboxylase; Ornithine decarboxylase; Messenger RNA; Antizyme; Expression; Binding; Protein; Termination; Elongation; Initiation
Publication Date:
2010
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: University College Cork
Funder(s): Science Foundation Ireland
Citation(s): Ivanov, I. P., Atkins, J. F. and Michael, A. J. (2010) 'A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation', Nucleic Acids Research, 38(2), pp. 353-359. doi: 10.1093/nar/gkp1037
Publisher(s): Oxford University Press
File Format(s): application/pdf
Related Link(s): https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkp1037
First Indexed: 2017-11-15 06:30:08 Last Updated: 2017-11-23 06:30:10