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Experimental study on the influence of excipients on the heterogeneous crystallization and dissolution properties of an active pharmaceutical ingredient
Verma, Vivek; Peddapatla, Raghu V.G.; Crowley, Clare M.; Crean, Abina M.; Davern, Peter; Hudson, Sarah P.; Hodnett, Benjamin K.
This study is based on the heterogeneous nucleation of active pharmaceutical ingredients (APIs) in the presence of various excipients widely used in the pharmaceutical industry. Carbamazepine (CBMZ) was successfully crystallized in the presence of the following heterosurfaces: alpha/beta-lactose, beta-D-mannitol, micro crystalline cellulose, and carboxymethyl cellulose. The successful crystallization of CBMZ FIII in the presence of all the excipients was confirmed by powder X-ray diffraction and scanning electron microscopy, while CBMZ crystals' apposition was confirmed using in situ scanning electronic microscopy-Raman. A pronounced improvement in the dissolution of CBMZ FIII was observed when crystallized in the presence of excipients when compared with CBMZ FIII recrystallized using the same conditions in the absence of the excipients. The isolated solids could be simply tabletted by direct compression upon mixing with the desired amount of disintegrant and lubricant. Hence employing this process could potentially streamline the downstream process in pharmaceutical industries and also increase the throughput with reduced cost. ACCEPTED peer-reviewed
Keyword(s): heterogeneous nucleation; active pharmaceutical ingredients; excipients; carbamazepine
Publication Date:
2018
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: University of Limerick
Funder(s): Science Foundation Ireland
Citation(s): Crystal Growth and Design;18, (1), pp. 338-350
http://dx.doi.org/10.1021/acs.cgd.7b01336
12/RC/2275
Publisher(s): American Chemical Society
First Indexed: 2018-02-25 06:25:28 Last Updated: 2018-12-15 06:59:09