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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
Montagner, D.; Fresch, B.; Browne, K.; Gandin, V.; Erxleben, Andrea
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
Keyword(s): PERIPHERAL BENZODIAZEPINE-RECEPTOR; SELECTIVE LIGANDS; BINDING-AFFINITY; 18 KDA; TSPO; CANCER; SITES; MODEL
Publication Date:
2018
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: NUI Galway
Publisher(s): Royal Society of Chemistry
File Format(s): application/pdf
First Indexed: 2018-03-15 06:21:42 Last Updated: 2018-03-15 06:21:42