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Preparation of cytocompatible ITO neuroelectrodes with enhanced electrochemical characteristics using a facile anodic oxidation process
Vallejo-Giraldo, Catalina; Pampaloni, Niccolo Paolo; Pallipurath, Anuradha R.; Mokarian-Tabari, Parvaneh; O'Connell, John; Holmes, Justin D.; Trotier, Alexandre; Krukiewicz, Katarzyna; Orpella-Aceret, Gemma; Pugliese, Eugenia; Ballerini, Laura; Kilcoyne, Michelle; Dowd, Eilis; Quinlan, Leo R.; Pandit, Abhay; Kavanagh, Paul; Biggs, Manus Jonathan Paul
Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm(-2) show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.
Keyword(s): Cytocompatibility; Electrodes; Functionalization; Indium tin oxide; Neural interfaces
Publication Date:
2017
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: University College Cork
Funder(s): Science Foundation Ireland
Citation(s): Vallejo-Giraldo, C., Pampaloni, N. P., Pallipurath, A. R., Mokarian-Tabari, P., O'Connell, J., Holmes, J. D., Trotier, A., Krukiewicz, K., Orpella-Aceret, G., Pugliese, E., Ballerini, L., Kilcoyne, M., Dowd, E., Quinlan, L. R., Pandit, A., Kavanagh, P. and Biggs, M. J. P. (2018) 'Preparation of cytocompatible ITO neuroelectrodes with enhanced electrochemical characteristics using a facile anodic oxidation process', Advanced Functional Materials, 28(12), 1605035 (18pp). doi: 10.1002/adfm.201605035
Publisher(s): John Wiley & Sons Inc.
File Format(s): application/pdf
Related Link(s): https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201605035
First Indexed: 2018-07-31 06:32:01 Last Updated: 2018-09-06 06:30:55