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Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.
Early, James O; Menon, Deepthi; Wyse, Cathy A; Cervantes-Silva, Mariana P; Zaslona, Zbigniew; Carroll, Richard G; Palsson-McDermott, Eva M; Angiari, Stefano; Ryan, Dylan G; Corcoran, Sarah E; Timmons, George; Geiger, Sarah S; Fitzpatrick, Darren J; O'Connell, Daniel; Xavier, Ramnik J; Hokamp, Karsten; O'Neill, Luke AJ; Curtis, Anne M
<p>The original article is available at<a href="http://www.pnas.org"> http://www.pnas.org</a></p> <p>A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal that the core molecular clock protein, BMAL1, controls the mRNA expression of</p>
Keyword(s): Circadian Clock; BMAL1; Oxidative Stress; Inflammation; Macrophage.; Life Sciences
Publication Date:
2018
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D4, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(36):E8460-E8468.
Publisher(s): National Academy of Sciences
File Format(s): application/pdf
Related Link(s): https://epubs.rcsi.ie/mctart/114
First Indexed: 2018-08-23 07:17:18 Last Updated: 2018-10-02 07:17:59