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The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon.
Ward, Joseph B J; Mroz, Magdalena S; Keely, Stephen J
<p>This is the peer reviewed version of the following article: Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11 which has been published in final form at 10.1111/nmo.12148. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.</p> <p>Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic-induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.</p>
Keyword(s): Animals; Bile Acids and Salts; Cholic Acids; Cholinergic Neurons; Colon; Epithelial Cells; Organ Culture Techniques; Rats; Receptors; G-Protein-Coupled; Medical Molecular Biology; Medical Sciences
Publication Date:
2013
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11
Publisher(s): Wiley
File Format(s): application/pdf
Related Link(s): https://epubs.rcsi.ie/molmedart/41
First Indexed: 2018-08-24 07:17:32 Last Updated: 2018-08-24 07:17:32