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Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome
Wu, Dan; Cheung, Shane; O'Sullivan, Corry James; Gao, Yinghua; Chen, Zhi-Long; O'Shea, Donal F
<p>The original paper is available at https://pubs.rsc.org</p> <p>The contribution of imaging with near infrared (NIR) fluorophores to the elucidation of complex biological processes continues to rapidly expand. New tools for mild selective bioconjugation are strongly desirable for the construction of NIR labelled biomolecules. This work presents the synthesis and evaluation of a strained alkyne substituted NIR BF2-azadipyrromethene (NIR-AZA) which can conjugate in water with azido-homoalanine and cRGD peptide within 30 min at rt. Imaging analysis of the NIR-AZA–cRGD conjugate in vitro and in vivo showed efficient cellular uptake and good in vivo tumor targeting properties, illustrating the potential for translation to clinical imaging.</p>
Keyword(s): Fluorescence imaging; BF2 azadipyrromethene fluorochrome; Chemistry; Medicinal-Pharmaceutical Chemistry; Medicine and Health Sciences
Publication Date:
2016
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Wu D, Cheung S, O'Sullivan CJ, Gao Y, Chen Zl, O'Shea DF. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances. 2016;6:87373-87379
Publisher(s): Royal Society of Chemistry
File Format(s): application/pdf
Related Link(s): https://epubs.rcsi.ie/pmcart/25
First Indexed: 2018-09-07 07:15:10 Last Updated: 2018-09-07 07:15:10