Institutions | About Us | Help | Gaeilge
rian logo

Go Back
Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma
Wolsztynski, Eric; O'Sullivan, Finbarr; Keyes, Eimear; O'Sullivan, Janet; Eary, Janet F.
Intratumoral heterogeneity biomarkers derived from positron emission tomography (PET) imaging with fluorodeoxyglucose (FDG) are of interest for a number of cancers, including sarcoma. A range of radiomic texture variables, adapted from general methodologies for image analysis, has shown promise in the setting. In the context of sarcoma, our group introduced an alternative model-based approach to the measurement of heterogeneity. In this approach, the heterogeneity of a tumor is characterized by the extent to which the 3-D FDG uptake pattern deviates from a simple elliptically contoured structure. By using a nonparametric analysis of the uptake profile obtained from this spatial model, a variable assessing the metabolic gradient of the tumor is developed. The work explores the prognostic potential of this new variable in the context of FDG-PET imaging of sarcoma. A mature clinical series involving 197 patients, 88 of whom have complete time-to-death information, is used. Texture variables based on the imaging data are also evaluated in this series and a range of appropriate machine learning methodologies are then used to explore the complementary prognostic roles for structure and texture variables. We conclude that both texture-based and model-based variables can be combined to achieve enhanced prognostic assessments of outcome for patients with sarcoma based on FDG-PET imaging information.
Keyword(s): Statistical modeling; Statistical analysis; Neural networks; Positron emission tomography; Model-based design; 3D modeling; Feature selection; Principal component analysis; Tumors
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: University College Cork
Funder(s): Science Foundation Ireland
Citation(s): Wolsztynski, E., O’Sullivan, F., Keyes, E., O’Sullivan, J. and Eary, J. F. (2018) 'Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma', Journal of Medical Imaging, 5(2), 024502 (16pp). doi: 10.1117/1.JMI.5.2.024502
Publisher(s): Society of Photo-optical Instrumentation Engineers (SPIE)
File Format(s): application/pdf
Related Link(s):
First Indexed: 2018-09-25 06:31:04 Last Updated: 2018-09-28 06:32:25