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Biochemical investigations of hyperhomocysteinemia
Betts, Mary Victoria
THESIS 5895 Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first part of this thesis describes attempts to investigate the cellular basis for the accumulation of homocysteine seen in mild hyperhomocysteinemia. A method involving radiolabelling of methionine and its derivatives was designed to determine the fate of homocysteine in cells. It was hoped that such a system might provide insight into the factors that contribute to hyperhomocysteinemia. This study was carried out in nine control (non hyperhomocysteinemic) individuals and in seven vascular disease subjects, four of whom had mild hyperhomocysteinemia.
Keyword(s): Biochemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2000
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Mary Victoria Betts, 'Biochemical investigations of hyperhomocysteinemia', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000, pp 277
Publisher(s): Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
Supervisor(s): Collins, Paddy
First Indexed: 2018-12-08 06:20:37 Last Updated: 2018-12-08 06:20:37