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Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael; Lowery, Aoife
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
Keyword(s): breast reconstruction; mastectomy; adipose-derived stem cells; tissue engineering; adipose tissue engineering; breast cancer; skin-sparing mastectomy; autologous fat transfer; stromal-vascular fraction; locoregional recurrence risk; promote cancer progression; acellular dermal matrix; acid-based scaffolds; quality-of-life; term-follow-up; extracellular-matrix
Publication Date:
Type: Journal article
Peer-Reviewed: Unknown
Institution: NUI Galway
Publisher(s): SAGE Publications
First Indexed: 2019-03-23 06:26:02 Last Updated: 2019-03-23 06:26:02