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High risk HPV testing following treatment for cervical intraepithelial neoplasia
Molloy, M.; Comer, R.; Rogers, P.; Dowling, Maura; Meskell, P.; Asbury, K.; O'Leary, M.
To determine the results of combined cytology and high-risk human papilloma virus (HR HPV) tests at 6 and 18 months postcolposcopy treatment at one Irish colposcopy centre.All women who attended the centre's colposcopy smear clinic for a co-test 6 months (initial test) posttreatment were included in the audit (n = 251).The results revealed negative HR HPV for 79 % (n = 198) of women tested 6 months after treatment and positive results for 21 % (n = 53). HR HPV testing was more sensitive than cytology and led to early detection of residual disease. No women with negative HR HPV had high-grade cytology.HR HPV is more sensitive than cytology for detection of persistent CIN. However, 19 women with positive HR HPV had normal colposcopy with no persistent CIN detected. A national cost-benefit analysis is recommended to determine the value of the second co-test.
Keyword(s): Audit; Cervical intraepithelial neoplasia; Colposcopy; HPV DNA tests; Papanicolaou test; LOOP EXCISION; PREVENTION; PREDICTION; DISEASE
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: NUI Galway
Publisher(s): Springer Verlag
First Indexed: 2019-03-23 06:45:10 Last Updated: 2019-03-23 06:45:10