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Maristem-stem cells of marine/aquatic invertebrates: from basic research to innovative applications
Ballarin, Loriano; Rinkevich, Baruch; Bartscherer, Kerstin; Burzynski, Artur; Cambier, Sebastien; Cammarata, Matteo; Domart-Coulon, Isabelle; Drobne, Damjana; Encinas, Juanma; Frank, Uri; Geneviere, Anne-Marie; Hobmayer, Bert; Löhelaid, Helike; Lyons, Daniel; Martinez, Pedro; Oliveri, Paola; Peric, Lorena; Piraino, Stefano; Ramšak, Andreja; Rakers, Sebastian
The "stem cells" discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on stem cells from organisms outside the classical vertebrate (e.g., human, mouse, and zebrafish) and invertebrate (e.g., Drosophila, Caenorhabditis) models have not been pursued vigorously. Marine/aquatic invertebrates constitute the largest biodiversity and the widest phylogenetic radiation on Earth, from morphologically simple organisms (e.g., sponges, cnidarians), to the more complex mollusks, crustaceans, echinoderms, and protochordates. These organisms contain a kaleidoscope of MISC-types that allow the production of a large number of novel bioactive-molecules, many of which are of significant potential interest for human health. MISCs further participate in aging and regeneration phenomena, including whole-body regeneration. For years, the European MISC-community has been highly fragmented and has established scarce ties with biomedical industries in an attempt to harness MISCs for human welfare. Thus, it is important to (i) consolidate the European community of researchers working on MISCs; (ii) promote and coordinate European research on MISC biology; (iii) stimulate young researchers to embark on research in MISC-biology; (iv) develop, validate, and share novel MISC tools and methodologies; (v) establish the MISC discipline as a forefront interest of biomedical disciplines, including nanobiomedicine; and (vi) establish collaborations with industries to exploit MISCs as sources of bioactive molecules. In order to fill the recognized gaps, the EC-COST Action 16203 "MARISTEM" has recently been launched. At its initial stage, the consortium unites 26 scientists from EC countries, Cooperating countries, and Near Neighbor Countries. This study is supported by the European Cooperation in Science & Technology program (EU COST). Grant title: “Stem cells of marine/aquatic invertebrates: from basic research to innovative applications” (MARISTEM). The project idea developed as a direct outcome of a EuroMarine (European Marine Research Network) working group meeting held in Padua on 9–10 March 2016.
Keyword(s): aging; bioactive molecules; blue biotechnology; cancer; cell culture; COST Action; Europe; marine/aquatic invertebrates; regeneration; stem cells; SEA-URCHIN EGGS; REGENERATION; EVOLUTION; QUINONES; PROTEIN; UNITS
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Contributor(s): European Cooperation in Science and Technology
Institution: NUI Galway
Publisher(s): MDPI
File Format(s): application/pdf
First Indexed: 2019-03-23 06:51:36 Last Updated: 2019-09-20 07:02:05