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An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma
O'Hanlon, DM; Kerin, MJ; Kent, P; Maher, D; Grimes, H; Given, HF
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
Keyword(s): breast neoplasia; ca 15-3; tumor marker; monoclonal-antibodies; cancer patients; antigen levels; ca15-3; tumors; df3
Publication Date:
Type: Journal article
Peer-Reviewed: Unknown
Institution: NUI Galway
Publisher(s): Springer Nature
First Indexed: 2019-03-23 06:52:03 Last Updated: 2019-03-23 06:52:03