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Adverse Drug reactions in an Ageing PopulaTion (ADAPT) study protocol: a cross-sectional and prospective cohort study of hospital admissions related to adverse drug reactions in older patients.
Cahir, Caitriona; Curran, Carmel; Byrne, Catherine; Walsh, Caroline; Hickey, Anne, Professor; Williams, David; Bennett, Kathleen
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/7/6/e017322.long">bmjopen.bmj.com</a></p> <p><strong>INTRODUCTION:</strong> Older people experience greater morbidity with a corresponding increase in medication use resulting in a potentially higher risk of adverse drug reactions (ADRs). The aim of this study is to determine the prevalence and characteristics of ADR-related hospital admissions among older patients (≥65 years) and their associated health and cost outcomes.</p> <p><strong>METHODS AND ANALYSIS:</strong> The proposed study will include a cross-sectional study of ADR prevalence in all patients aged ≥65 years admitted acutely to a large tertiary referral hospital in Ireland over a 9-month period (2016-2017) and a prospective cohort study of patient-reported health outcomes and costs associated with ADR-related hospital admissions. All acute medical admissions will be screened for a suspected ADR-related hospital admission. A number of validated algorithms will be applied to assess the type, causative medications, preventability and severity of each ADR. ADRs will be determined, using a consensus method, by an expert panel. Patients who provide consent will be followed up 3 months post-discharge to establish patient-reported health outcomes (health service use, health-related quality of life, adherence) and costs associated with ADR-related hospital admissions. A random sample of patients admitted to hospital without a suspected ADR will be invited to take part in the study as a control group.</p> <p><strong>ETHICS AND DISSEMINATION:</strong> Ethical approval was obtained from Beaumont Hospital Ethics Committee. Findings will be disseminated through presentations and peer-reviewed publications.</p>
Keyword(s): Aged; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Health Care Costs; Health Services; Humans; Ireland; Medication Adherence; Patient Admission; Patient Reported Outcome Measures; Prevalence; Prospective Studies; Quality of Life; Research Design; Risk Factors; Psychology
Publication Date:
2017
Type: Journal article
Peer-Reviewed: Yes
Institution: Royal College of Surgeons in Ireland
Citation(s): Cahir C, Curran C, Byrne C, Walsh C, Hickey A, Williams DJ, Bennett K. Adverse Drug reactions in an Ageing PopulaTion (ADAPT) study protocol: a cross-sectional and prospective cohort study of hospital admissions related to adverse drug reactions in older patients. BMJ Open. 2017;7(6):e017322.
Publisher(s): BMJ Publishing Group
File Format(s): application/pdf
Related Link(s): https://epubs.rcsi.ie/psycholart/132
First Indexed: 2019-04-12 07:15:37 Last Updated: 2019-04-12 07:15:37