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Synthesis and physical evaluation of lanthanide ion based complexes for the hydrolysis of phosphodiesters
Fanning, Ann-Marie
THESIS 8644 This thesis describes the synthesis and complexation characteristics of a series of cyclen based lanthanide complexes, designed for hydrolysis of phosphodiesters. Chapter one gives an introduction into the field of phosphodiester hydrolysis. This chapter will look at many of the advances made in the area of phosphodiester hydrolysis, with particular emphasis on RNA cleavage by lanthanide ion complexes. Firstly, the mechanism of this reaction and the significant role played by the metal ions will be discussed. This will be followed by a review of cyclen based lanthanide complexes that have been used to promote the hydrolysis of phosphodiesters. Finally, examples of highly efficient and selective systems capable of hydrolysis in a site-specific manner will be discussed.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2006
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Ann-Marie Fanning, 'Synthesis and physical evaluation of lanthanide ion based complexes for the hydrolysis of phosphodiesters', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2006, pp 287
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Gunnlaugsson, Thorfinnur
First Indexed: 2019-05-01 06:52:14 Last Updated: 2019-05-01 06:52:14