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Synthesis, biological evaluation and subsequent SAR of four novel families of alkyliphatic twin drugs
Corcoran, Jonathan
THESIS 8398 The I2-IBS is a well known binding site widely distributed in the body of both animals and humans. It is suspected that they are an allosteric binding site of MAO-B. They have also been linked to several conditions such as Alzheimer’s and neuro protection. Their main physiological function appears to be the ability of I2-IBS ligands to attenuate the tolerance to opiod drugs. This link between the I2-IBS and the u-opioid receptor system has made I2-IBS binding sites of pharmalogical importance.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2007
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Jonathan Corcoran, 'Synthesis, biological evaluation and subsequent SAR of four novel families of alkyliphatic twin drugs', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2007, pp 226
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Rozas, Isabel
First Indexed: 2019-05-01 06:52:15 Last Updated: 2020-07-28 08:26:23