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Computational study of the a1A-adrenoceptor and its ligands
Kinsella, Gemma
THESIS 7919 Adrenoceptors belong to the 'super-family' of seven transmembrane domain receptors known as G protein coupled receptors (GPCRs), which produce their effects through coupling with G proteins. Nine different subtypes of adrenoceptors (ARs) have been identified based on the results of pharmacological and molecular cloning studies, of which the ?1-A R subtypes are associated with the condition Benign Prostatic Hyperplasia (BPH). BPH effects 50 % of men over the age of 50 and due to increased life expectancy the proportion of men suffering from BPH will increase significantly over the coming years. Prostatic smooth muscle contraction occurs predominantly, if not exclusively, via the ?1A-AR subtype and antagonists selective for this particular receptor might be most useful in alleviating the urological symptoms of BPH which include increased frequency in urination, nocturia, a poor urine stream and hesitancy or delay in starting flow.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Gemma Kinsella, 'Computational study of the a1A-adrenoceptor and its ligands', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2005, pp 224
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Watson, Graeme
First Indexed: 2019-05-02 06:11:14 Last Updated: 2019-11-29 07:08:47