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The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold
McMahon, Louise Ann
THESIS 8216 Adult mesenchymal stem cells (MSCs) offer great potential in tissue engineering applications as they can be directed to differentiate along numerous lineages to produce a range of skeletal tissues, including the chondrogenic lineage. The importance of mechanical loading for the maintenance of skeletal tissues is well reported. The aim of this thesis was to demonstrate that the application of cyclic tensile strain to MSC-seeded collagen-GAG scaffolds regulates the chondrogenic differentiation process, in the presence of chondrogenic growth factors.
Keyword(s): Mechanical and Manufacturing Engineering, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2007
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Louise Ann McMahon, 'The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007, pp 241
Publisher(s): Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering
Supervisor(s): Prendergast., Patrick J.
First Indexed: 2019-05-03 06:10:47 Last Updated: 2019-05-03 06:10:47