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An Audit of Neural Tube Defects in the Republic Of Ireland for 2012-2015
McDonnell, R.; Delany, V; O’Mahony, M.T.; Turner, Michael J.; et al.
Neural tube defects (NTD) are potentially preventable in two-thirds of cases by periconceptional maternal Folic Acid (FA) supplementation. A national audit for the years 2009-11 showed no decline in NTD rates over twenty years. The aim of this national audit was to determine trends/rates and inform revision of national FA supplementation and food fortification strategies. Of 274,732 live and stillbirths there were 121(42.0%) cases of anencephaly, 136(47.2%) cases of spina bifida and 31(10.8%) cases of encephalocoele giving a total of 288 and overall rate of 1.05/1000 compared with 1.04/1000 in 2009-11(NS). In the 184 women where the information was available, only 29.9%(n=55) reported starting FA before pregnancy. The number of cases diagnosed antenatally was 91%(n=262) and 53%(n=154) were live-born. This audit confirms that over a generation, healthcare interventions have not succeeded in decreasing the number of pregnancies in Ireland complicated by NTD, and that revised strategies need to be developed and implemented.
Keyword(s): Neural tube defects (NTD); Folic Acid (FA); Stillbirths; Anencephaly; Spina bifida; Encephalocoele
Publication Date:
2019
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): Irish Medical Organisation
First Indexed: 2019-05-11 06:31:33 Last Updated: 2019-05-11 06:31:33