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An investigation into the effect of A beta on cultured cortical neurons
Boland, Barry
THESIS 7144 Accumulation of the endogenously produced beta-amyloid (A?) peptide in senile plaques is involved in the development of Alzheimer?s disease. This study reports on potential molecular mechanisms underlying the cell death induced by A? (1-40) (2 ?M) on cultured primary cortical neurons. Particular attention was paid to the downstream effects of in A?-induced increase in [Ca 2+]i and on intracellular organelles that included the mitochondria, lysosomes and endoplasmic reticulum.
Keyword(s): Physiology, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2003
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Barry Boland, 'An investigation into the effect of A beta on cultured cortical neurons', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2003, pp 392
Publisher(s): Trinity College (Dublin, Ireland). Department of Physiology
Supervisor(s): Campbell, Veronica
First Indexed: 2019-05-16 06:12:31 Last Updated: 2019-10-04 07:03:15