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Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia |
Kavanagh, Yvonne
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THESIS 6832 The work presented in this thesis describes the synthesis of two ruthenium
oligodeoxynucleotide (ODN) conjugates and their application as potential
photoactive antisense agents in a model Chronic Myeloid Leukaemia (CML) system.
The target 34mer ODN sequence chosen for the model system represents the
messenger RNA sequence transcribed from the breakpoint region of the bcr/abl
oncogene on the Philadelphia chromosome, an abnormal chromosome specific to
CML cells. The overall aim of this work is augmentation of an antisense effect
through site-specific photochemical targeting of the target 34mer ODN sequence
thus, in theory, suppressing leukaemic mRNA expression and subsequent oncoprotein
production.
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Keyword(s):
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Chemistry, Ph.D.; Ph.D. Trinity College Dublin |
Publication Date:
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2002 |
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Type:
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Doctoral thesis |
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Peer-Reviewed:
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Unknown |
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Language(s):
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English |
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Institution:
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Trinity College Dublin |
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Citation(s):
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Yvonne Kavanagh, 'Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2002, pp 254 |
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Publisher(s):
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Trinity College (Dublin, Ireland). School of Chemistry |
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Supervisor(s):
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Corish, John |
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First Indexed:
2019-07-27 06:11:36 Last Updated:
2019-07-27 06:11:36 |
