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Towards a comprehensive system for the recognition of double helical DNA : Components for base pair recognition in the major groove
Kelleher, Mary Rose
THESIS 6822 This thesis describes the attempted synthesis of sequence selective double-stranded DNA-binding ligands. It had been intended to provide a comprehensive DNA recognition system via two different tricyclic heterocyclic motifs. The (5,5,5) pyrrolo [2', 3' : 4, 5] thieno [3, 2-d] thiazole system 1.52 was proposed to recognise A-T/T-A base pairs, and the functionalised (6,4,6)-tricyclic heterocyclic system 1.56 would recognise G-C/C-G base pairs.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2002
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Mary Rose Kelleher, 'Towards a comprehensive system for the recognition of double helical DNA : Components for base pair recognition in the major groove', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2002, pp 200
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Davis, Tony
First Indexed: 2019-07-27 06:11:36 Last Updated: 2019-07-27 06:11:36