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Enantioselective receptors via one-bead one-compound combinatorial libraries
Kelly, Patricia Amy
THESIS 7366 Chapter 1 describes the overall aim of this project, which is to extend the range of steroid-based receptors synthesised by the Davis group, using the combinatorial chemistry approach instead of traditional design and synthesis methods. The importance of an efficient method of screening combinatorial libraries for "hits", and the application of such a technique to the discovery of steroid-based enantioselective receptors, are described in Chapter 2. The target assay, wherein a solid-phase bound combinatorial library o f receptors is exposed to racemic guest, of which each enantiomer is differentially colour-tagged, is also described. Chapter 3 describes a method whereby a semi-quantitative estimate of the enantioselectivity of individual bead-bound receptors may be obtained, by use of isotopically differentiated enantiomers.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
2003
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Patricia Amy Kelly, 'Enantioselective receptors via one-bead one-compound combinatorial libraries', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2003, pp 180
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Corish, John
First Indexed: 2019-07-27 06:11:36 Last Updated: 2019-07-27 06:11:36