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Family-based molecular genetic studies in bipolar affective disorder
Segurado, Ricardo
THESIS 7372 This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample consisted of affected sibling pairs (ASPs), where one sibling had a diagnosis of bipolar I disorder (BPI), and the other one of a range of broader diagnoses within the affective spectrum. Initial studies focused on the investigation of a candidate gene, tyrosine hydroxylase (TH), for association to BPD in an Irish pedigree sample (216 individuals). This gene revealed no evidence for association with the phenotype, possibly due to lack of statistical power of the sample, or other confounding factors.
Keyword(s): Genetics, Ph.D.; Ph.D. Trinity College Dublin
Publication Date:
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Ricardo Segurado, 'Family-based molecular genetic studies in bipolar affective disorder', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2003, pp 301
Publisher(s): Trinity College (Dublin, Ireland). Department of Genetics
Supervisor(s): Gill, Michael
First Indexed: 2019-07-31 06:14:45 Last Updated: 2019-07-31 06:14:45