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3D-Printed Peptide-Hydrogel Nanoparticle Composites for Surface-Enhanced Raman Spectroscopy Sensing
Almohammed, Sawsan; Alruwaili, Maha; Reynaud, Emmanuel G.; Redmond, Gareth; Rice, James H.; Rodriguez, Brian J.
Precise control over the arrangement of plasmonic nanomaterials is critical for label-free single-molecule surface-enhanced Raman spectroscopy (SERS)-based sensing applications. SERS templates should provide high sensitivity and reproducibility and be cost-effective and easy to prepare. Additive manufacturing by extrusion-based three-dimensional (3D) printing is an emerging technique for the spatial arrangement of nanomaterials and is a method that may satisfy these SERS template requirements. In this work, we use 3D printing to produce sensitive and reproducible SERS templates using a fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) hydrogel loaded with silver or gold nanoparticles. The Fmoc-FF template allows the detection of low Raman cross-section molecules such as adenine at concentrations as low as 100 pM. Enterprise Ireland European Commission Horizon 2020 Science Foundation Ireland The Ministry of Higher Education of Saudi Arabia under the King Abdullah Scholarship Program
Keyword(s): 3D bioprinting; Additive manufacturing; Peptides; Fmoc; Diphenylalanine; Raman; SERS; SERRS
Publication Date:
2019
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): American Chemical Society (ACS)
First Indexed: 2019-08-14 06:16:36 Last Updated: 2020-03-14 06:17:38