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The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample.
O'Halloran, Aisling; Kenny, Rose
Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD). Material and methods: Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware; Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence of AMD. Results: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs, 288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and age, the relationship between grading-confirmed AMD and plasma L was positive and significant (p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ? 0.132 ?mol) and Group 4 (mean = 0.2040 ? 0.121 ?mol/L) were significantly lower than Group 1 (mean = 0.4691 ? 0.0.372 ?mol/L) and Group 3 (mean = 0.3176 ? 0.0.235 ?mol/L). Supplement use was reported by 41.7% and 17.1% of participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4, respectively. Conclusion: A belief that one suffers from AMD, whether justified or not, is associated with supplement use and with higher plasma concentrations of L.
Keyword(s): Lutein; Zeaxanthin; Awareness; Supplements; Age-related macular degeneration
Publication Date:
2017
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): Moran, R., Beatty, S., Stack, J., O'Halloran, A.M., Feeney, J., Akuffo, K.O., Peto, T., Kenny, R.A., Nolan, J.M. The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample, Current eye research, 2017, 383-390
Related Link(s): https://www.tandfonline.com/doi/full/10.1080/02713683.2017.1403633
First Indexed: 2019-08-25 06:10:19 Last Updated: 2020-10-29 06:16:03